磷酸盐饥饿依赖的铁动员诱导 CLE14 表达，通过 CLV2/PEPR2 信号触发根分生组织分化。
Phosphate Starvation-Dependent Iron Mobilization Induces CLE14 Expression to Trigger Root Meristem Differentiation through CLV2/PEPR2 Signaling.
机构信息
Metabolic Engineering Group, Unidad de Genómica Avanzada, Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO) del Centro de Investigación y Estudios Avanzados, Km. 9.6 Libramiento Norte Carr. Irapuato-León, 36821 Irapuato, Guanajuato, Mexico; Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apartado Postal 510-3, Cuernavaca 62250, Morelos, Mexico.
Metabolic Engineering Group, Unidad de Genómica Avanzada, Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO) del Centro de Investigación y Estudios Avanzados, Km. 9.6 Libramiento Norte Carr. Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.
出版信息
Dev Cell. 2017 Jun 5;41(5):555-570.e3. doi: 10.1016/j.devcel.2017.05.009.
Low inorganic phosphate (Pi) availability causes terminal differentiation of the root apical meristem (RAM), a phenomenon known as root meristem exhaustion or determined growth. Here, we report that the CLE14 peptide acts as a key player in this process. Low Pi stress induces iron mobilization in the RAM through the action of LPR1/LPR2, causing expression of CLE14 in the proximal meristem region. CLV2 and PEPR2 receptors perceive CLE14 and trigger RAM differentiation, with concomitant downregulation of SHR/SCR and PIN/AUXIN pathway. Our results reveal multiple steps of the molecular mechanism of one of the most physiologically important root nutrient responses.
低无机磷酸盐（Pi）供应导致根尖分生组织（RAM）的末端分化，这一现象被称为根分生组织衰竭或决定生长。在这里，我们报告 CLE14 肽在这个过程中起着关键作用。低 Pi 胁迫通过 LPR1/LPR2 的作用在 RAM 中引起铁动员，导致 CLE14 在近轴分生组织区域表达。CLV2 和 PEPR2 受体感知 CLE14 并触发 RAM 分化，同时 SHR/SCR 和 PIN/AUXIN 途径下调。我们的结果揭示了生理上最重要的根养分响应之一的分子机制的多个步骤。
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