Targeted Drug Delivery Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Biomed Pharmacother. 2017 Aug;92:726-731. doi: 10.1016/j.biopha.2017.05.113. Epub 2017 Jun 4.
Atypical antipsychotics particularly olanzapine are associated with obesity and serious metabolic disturbances. As green tea (Camellia sinensis) is generally associated with beneficial effects on obesity and other metabolic disturbances, this study was undertaken to evaluate the effect of green tea aqueous extract (GTAE) on olanzapine induced weight gain and metabolic abnormalities in rats. Male Wistar rats were divided into eight groups: control, olanzapine (5mg/kg/day, IP.), GTAE (25, 50 and 100mg/kg/day, IP.) plus olanzapine and GTAE (25, 50 and 100mg/kg/day, IP.). Treatments were continued for 11 days. Body weight gain, average food and water intake were measured during the experiment. Plasma lipid, glucose and leptin levels, mean systolic blood pressure and total locomotion were evaluated at the end of experiment. Olanzapine induced significant weight gain at the end of treatment (10.38% of body weight) when compared to control (3.13% of body weight) in male Wistar rats. Average food and water intake were increased by olanzapine treatment. 11days olanzapine administration led to hyperleptinemia, hyperglycemia and dyslipidemia. Olanzapine also increased mean systolic blood pressure and decreased total locomotion. GTAE decreased significantly body weight gain and average food and water intake, improved the changes in lipid profile as well as fasting blood glucose, and finally decreased hyperleptinemia and hypertension induced by olanzapine. Results of this study demonstrated that GTAE could exert protective effects against olanzapine induced obesity partially due to its lowering effect on leptin. GTAE improved other metabolic abnormalities including dyslipidemia, hyperglycemia and hypertension induced by olanzapine in rats.
非典型抗精神病药，特别是奥氮平，与肥胖和严重的代谢紊乱有关。由于绿茶（Camellia sinensis）通常与肥胖和其他代谢紊乱有益，因此进行了这项研究，以评估绿茶水提取物（GTAE）对奥氮平诱导的大鼠体重增加和代谢异常的影响。雄性 Wistar 大鼠分为八组：对照组、奥氮平（5mg/kg/天，IP.）、GTAE（25、50 和 100mg/kg/天，IP.）加奥氮平以及 GTAE（25、50 和 100mg/kg/天，IP.）。治疗持续 11 天。在实验过程中测量体重增加、平均食物和水摄入量。在实验结束时评估血浆脂质、葡萄糖和瘦素水平、平均收缩压和总运动。与对照组（体重增加 3.13%）相比，奥氮平治疗可导致雄性 Wistar 大鼠在治疗结束时体重显著增加（体重增加 10.38%）。奥氮平治疗可增加平均食物和水摄入量。11 天奥氮平给药可导致高瘦素血症、高血糖和血脂异常。奥氮平还可增加平均收缩压并降低总运动量。GTAE 可显著降低体重增加和平均食物和水摄入量，改善脂质谱以及空腹血糖的变化，最后降低奥氮平引起的高瘦素血症和高血压。这项研究的结果表明，GTAE 可通过降低瘦素水平对奥氮平引起的肥胖发挥保护作用。GTAE 可改善其他代谢异常，包括奥氮平引起的大鼠血脂异常、高血糖和高血压。
