Oskouei Zahra, Ghasemzadeh Rahbardar Mahboobeh, Hosseinzadeh Hossein
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2023;26(7):738-752. doi: 10.22038/IJBMS.2023.65997.14512.
Metabolic syndrome (MetS) is known as a global health challenge with different types of health conditions such as hypertension, hyperglycemia, the increasing prevalence of obesity, and hyperlipidemia. Despite much recent scientific progress, the use of traditional herbal medicines with fewer side effects is increasing worldwide. , the second-largest orchid genus, has been used as a natural source of drugs for the treatment of MetS. The beneficial effects of , including anti-hypertension, anti-hyperglycemia, anti-obesity, and anti-hyperlipidemic against MetS have been shown in the scientific evidence. The anti-oxidant and lipid-lowering effects of modulate hyperlipidemia via reducing lipid accumulation and maintaining lipid metabolism. Restoring pancreatic beta cells and regulating the insulin signaling pathway are involved in its antidiabetic properties. The hypotensive effects contribute to increasing nitric oxide (NO) generation and inhibiting extracellular signal-regulated kinase (ERK) signaling. More research projects, especially clinical trials, are needed to investigate the safety, efficacy, and pharmacokinetics of in patients. This review article provides, for the first time, comprehensive information about the efficacy of different species of . The described species can be a source of medicines for the treatment of MetS, which are reported in various evidence.
代谢综合征（MetS）是一项全球性的健康挑战，伴随着高血压、高血糖、肥胖症患病率上升以及高脂血症等不同类型的健康问题。尽管最近取得了许多科学进展，但副作用较少的传统草药在全球范围内的使用仍在增加。万代兰属，作为第二大兰花属，已被用作治疗代谢综合征的天然药物来源。科学证据表明，万代兰属对代谢综合征具有有益作用，包括抗高血压、抗高血糖、抗肥胖和抗高脂血症。万代兰属的抗氧化和降脂作用通过减少脂质积累和维持脂质代谢来调节高脂血症。恢复胰腺β细胞和调节胰岛素信号通路涉及其抗糖尿病特性。降压作用有助于增加一氧化氮（NO）的生成并抑制细胞外信号调节激酶（ERK）信号传导。需要更多的研究项目，尤其是临床试验，来研究万代兰属在患者中的安全性、有效性和药代动力学。这篇综述文章首次提供了关于不同万代兰属物种功效的全面信息。所描述的物种可以作为治疗代谢综合征的药物来源，这在各种证据中都有报道。
