Li Guoxing, Huang Jing, Xu Guozhang, Pan Xiaochuan, Qian Xujun, Xu Jiaying, Zhao Yan, Zhang Tao, Liu Qichen, Guo Xinbiao, He Tianfeng
Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, 38 Xueyuan Road, Beijing, 100191, China.
Ningbo Municipal Center for Disease Control and Prevention, Haishu District, 237 Yongfeng Road, Ningbo, 315010, China.
Environ Health. 2017 Jun 6;16(1):54. doi: 10.1186/s12940-017-0253-1.
Numerous studies have found associations between ambient fine particulate matter (PM) and increased mortality risk. However, little evidence is available on associations between PM and years of life lost (YLL). We aimed to estimate the YLL due to chronic obstructive pulmonary disease (COPD) mortality related to ambient PM exposure.
A time-series study was conducted based on the data on air pollutants, meteorological conditions and 18,472 registered COPD deaths in Ningbo, China, 2011-2015. The effects of PM on YLL and daily death of COPD were estimated, after controlling long term trend, meteorological index and other confounders.
The impact of PM on YLL due to COPD lasted for 5 days (lag 0-4). Per 10 μg/m increase in PM was associated with 0.91 (95%CI: 0.16, 1.66) years increase in YLL. The excess YLL of COPD mortality were 8206 years, and 0.38 day per person in Ningbo from 2011 to 2015. The exposure-response curve of PM and YLL due to COPD showed a non-linear pattern, with relatively steep at low levels and flattened out at higher exposures.. Furthermore, the effects were significantly higher in the elderly than those in the younger.
Our findings explored burden of PM on YLL due to COPD and highlight the importance and urgency of ambient PM pollution control and protection of the vulnerable populations.
大量研究发现环境细颗粒物(PM)与死亡率增加之间存在关联。然而,关于PM与寿命损失年数(YLL)之间关联的证据却很少。我们旨在估计因环境PM暴露导致的慢性阻塞性肺疾病(COPD)死亡所造成的YLL。
基于2011 - 2015年中国宁波的空气污染物数据、气象条件以及18472例登记的COPD死亡病例进行了一项时间序列研究。在控制长期趋势、气象指数和其他混杂因素后,估计了PM对COPD的YLL和每日死亡的影响。
PM对COPD导致的YLL的影响持续5天(滞后0 - 4天)。PM每增加10μg/m³与YLL增加0.91年(95%置信区间:0.16,1.66)相关。2011年至2015年宁波因COPD死亡导致的YLL过剩为8206年,人均0.38天。PM与COPD导致的YLL的暴露 - 反应曲线呈非线性模式,在低水平时相对陡峭,在较高暴露水平时趋于平缓。此外,老年人的影响显著高于年轻人。
我们的研究结果探讨了PM对COPD导致的YLL的负担,并强调了控制环境PM污染和保护脆弱人群的重要性和紧迫性。