School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Sci Rep. 2017 Jun 6;7(1):2877. doi: 10.1038/s41598-017-03296-6.
Angiogenesis plays a key role in tumor development and αβ integrin are overexpressed on the endothelial cell surface of newly forming vessels. F-Alfatide has favorable properties for αβ integrin targeting and showed potential for imaging angiogenesis with Positron Emission Tomography (PET)/computed tomography (CT). In this study, 13 patients with non-small cell lung cancer (NSCLC) who underwent F-Alfatide PET/CT before surgery were enrolled. The uptake of all dissected lymph nodes (LNs) of F-Alfatide were assessed visually and analyzed with a maximum and mean standard uptake value (SUV, SUV) and SUV ratios. LN metastases were pathologically confirmed and 20 of 196 LNs were malignant. All malignant LNs were successfully visualized on F-Alfatide PET/CT in patients and the sensitivity, specificity and accuracy was 100.0%, 94.9% and 95.4%, respectively. SUV, SUV and SUV ratios in malignant LNs were significantly higher than in benign LNs for NSCLC patients (P < 0.001). The same result was observed in patients with adenocarcinoma and squamous cell carcinoma (P < 0.001). The F-Alfatide parameter shows high sensitivity (83.9-100%), specificity (78.6-96.7%) and accuracy (81.7-96.9%) according to thresholds calculated from receiver operating characteristic curve. Our results suggest that F-Alfatide PET/CT is valuable in the diagnosis of metastatic LNs for NSCLC patients.
血管生成在肿瘤的发展中起着关键作用，αβ 整合素在新形成的血管内皮细胞表面过度表达。F-阿法肽对 αβ 整合素有很好的靶向作用，并显示出在正电子发射断层扫描（PET）/计算机断层扫描（CT）成像血管生成方面的潜力。在这项研究中，招募了 13 名接受 F-阿法肽 PET/CT 检查的非小细胞肺癌（NSCLC）患者。通过目测评估所有解剖淋巴结（LN）的 F-阿法肽摄取情况，并通过最大和平均标准摄取值（SUV，SUV）和 SUV 比值进行分析。通过病理证实 LN 转移，并在 196 个 LN 中发现 20 个恶性 LN。在患者中，F-阿法肽 PET/CT 成功地显示了所有恶性 LN，其敏感性、特异性和准确性分别为 100.0%、94.9%和 95.4%。对于 NSCLC 患者，恶性 LN 的 SUV、SUV 和 SUV 比值明显高于良性 LN（P<0.001）。腺癌和鳞状细胞癌患者也观察到相同的结果（P<0.001）。根据接受者操作特征曲线计算出的阈值，F-阿法肽参数显示出高敏感性（83.9-100%）、特异性（78.6-96.7%）和准确性（81.7-96.9%）。我们的研究结果表明，F-阿法肽 PET/CT 对 NSCLC 患者转移性 LN 的诊断具有重要价值。
