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计算机断层扫描X线摄影术在使用预后模型的非小细胞肺癌中的应用

Application of radiography of computed tomography in non-small cell lung cancer using prognosis model.

作者信息

Jin Yifeng, Lu Tao

机构信息

Department of Respiratory, Zhuji Affiliated Hospital of Shaoxing University, Zhuji 311800, China.

Department of Radiology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou City, Fujiang Province 350014, China.

出版信息

Saudi J Biol Sci. 2020 Apr;27(4):1066-1072. doi: 10.1016/j.sjbs.2020.02.016. Epub 2020 Mar 4.

Abstract

OBJECTIVE

Studying the diagnostic value of CT imaging in non-small cell lung cancer (NSCLC), and establishing a prognosis model combined with clinical characteristics is the objective, so as to provide a reference for the survival prediction of NSCLC patients.

METHOD

CT scan data of NSCLC 200 patients were taken as the research object. Through image segmentation, the radiology features of CT images were extracted. The reliability and performance of the prognosis model based on the optimal feature number of specific algorithm and the prognosis model based on the global optimal feature number were compared.

RESULTS

30-RELF-NB (30 optimal features, RELF feature selection algorithm and NB classifier) has the highest accuracy and AUC (area under the subject characteristic curve) in the prognosis model based on the optimal features of specific algorithm. Among the prognosis models based on global optimal features, 25-NB (25 global optimal features, naive Bayes classification algorithm classifier) has the highest accuracy and AUC. Compared with the prediction model based on feature training of specific feature selection algorithm, the overall performance and stability of the prediction model based on global optimal feature are higher.

CONCLUSION

The prognosis model based on the global optimal feature established in this paper has good reliability and performance, and can be applied to the CT radiology of NSCLC.

摘要

目的

研究CT成像在非小细胞肺癌(NSCLC)中的诊断价值,并建立结合临床特征的预后模型,为NSCLC患者的生存预测提供参考。

方法

以200例NSCLC患者的CT扫描数据为研究对象。通过图像分割,提取CT图像的放射学特征。比较基于特定算法的最优特征数量的预后模型和基于全局最优特征数量的预后模型的可靠性和性能。

结果

在基于特定算法最优特征的预后模型中,30-RELF-NB(30个最优特征、RELF特征选择算法和NB分类器)具有最高的准确率和受试者特征曲线下面积(AUC)。在基于全局最优特征的预后模型中,25-NB(25个全局最优特征、朴素贝叶斯分类算法分类器)具有最高的准确率和AUC。与基于特定特征选择算法特征训练的预测模型相比,基于全局最优特征的预测模型的整体性能和稳定性更高。

结论

本文建立的基于全局最优特征的预后模型具有良好的可靠性和性能,可应用于NSCLC的CT放射学研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0dd/7105650/5f97dc8ae345/gr3.jpg

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