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3
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4
Neural regulation of pancreatic islet cell mass and function.胰岛细胞团块与功能的神经调节
Diabetes Obes Metab. 2014 Sep;16 Suppl 1:87-95. doi: 10.1111/dom.12346.
5
Gene expression profiling in rat pancreas after ventromedial hypothalamic lesioning.大鼠下丘脑腹内侧核损伤后胰腺的基因表达谱分析。
Pancreas. 2010 Jul;39(5):627-32. doi: 10.1097/MPA.0b013e3181c52bc5.
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8
Cross platform microarray analysis for robust identification of differentially expressed genes.用于可靠鉴定差异表达基因的跨平台微阵列分析。
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The role of the autonomic nervous system in liver regeneration and apoptosis--recent developments.自主神经系统在肝脏再生与凋亡中的作用——最新进展
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Ventromedial hypothalamic lesion-induced vagal hyperactivity stimulates rat pancreatic cell proliferation.
Gastroenterology. 1996 Mar;110(3):885-93. doi: 10.1053/gast.1996.v110.pm8608899.

腹内侧下丘脑损伤后大鼠胰腺全转录组外显子阵列观察到的基因表达分析

Gene Expression Analysis in Rat Pancreas Observed with Whole-Transcript Exon Array after Ventromedial Hypothalamic Lesions.

作者信息

Kiba Takayoshi

机构信息

Division of Modern Medical Technology, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.

出版信息

Ann Neurosci. 2017 May;24(1):26-31. doi: 10.1159/000464420. Epub 2017 Apr 21.

DOI:10.1159/000464420
PMID:28588355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5448438/
Abstract

BACKGROUND

It was reported previously that using Affymetrix Rat Genome 230 2.0, one of a class of standard 3' based arrays, ventromedial hypothalamic (VMH) lesions affected the expressions of cell proliferation-related genes, neuron-related genes, and metabolism-related genes. The released Affymetrix Rat Gene 1.0 ST array has 2 major differences compared with standard 3' based arrays, including Rat Genome 230 2.0: it interrogates the entire mRNA transcript and uses DNA targets.

PURPOSE

This study is aimed at assessing the impact of these differences on the array performance.

METHODS

The study used Rat Gene 1.0 ST array, one of a class of whole-transcript rat exon arrays to examine the cellular mechanisms of gene regulation in the rat pancreas after VMH lesions.

RESULTS

Although the results showed that VMH lesions regulated genes involved in enzymes, metabolism, transport, binding differentiation, migration, morphology, apoptosis, neuron and immunity, the probes identified by these 2 arrays were remarkably different.

CONCLUSION

This study also confirmed that VMH lesions may affect the expression of many functional genes in rat pancreas.

摘要

背景

先前有报道称，使用一类基于3'端的标准阵列之一的Affymetrix大鼠基因组230 2.0芯片，腹内侧下丘脑（VMH）损伤会影响细胞增殖相关基因、神经元相关基因和代谢相关基因的表达。已发布的Affymetrix大鼠基因1.0 ST芯片与基于3'端的标准阵列（包括大鼠基因组230 2.0）相比有两个主要差异：它能检测整个mRNA转录本并使用DNA靶点。

目的

本研究旨在评估这些差异对阵列性能的影响。

方法

本研究使用大鼠基因1.0 ST芯片，这是一类全转录本大鼠外显子芯片，用于研究VMH损伤后大鼠胰腺中基因调控的细胞机制。

结果

尽管结果显示VMH损伤调控了参与酶、代谢、转运、结合、分化、迁移、形态、凋亡、神经元和免疫的基因，但这两种芯片鉴定出的探针有显著差异。

结论

本研究还证实VMH损伤可能影响大鼠胰腺中许多功能基因的表达。