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Umbelliprenin Mediates Its Apoptotic Effect by Hormesis: A Commentary.

作者信息

Gholami Omid

机构信息

Faculty of Medicine, Physiology and Pharmacology Department, Sabzevar University of Medical Sciences, Sabzevar, Iran.

出版信息

Dose Response. 2017 May 24;15(2):1559325817710035. doi: 10.1177/1559325817710035. eCollection 2017 Apr-Jun.

DOI:10.1177/1559325817710035
PMID:28588428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5446103/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/5446103/c257361c6154/10.1177_1559325817710035-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/5446103/c257361c6154/10.1177_1559325817710035-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/5446103/c257361c6154/10.1177_1559325817710035-fig1.jpg

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Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis.新疆阿魏中的伞形花内酯通过使细胞周期停滞于G1期并诱导半胱天冬酶依赖性凋亡来抑制人M4Beu转移性色素沉着恶性黑色素瘤细胞的生长。
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Umbelliprenin, a bioactive constituent from the genus has cytotoxic and apoptotic activity in a dose- and time-dependent manner.伞形花内酯,一种来自该属的生物活性成分,具有剂量和时间依赖性的细胞毒性和凋亡活性。
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本文引用的文献

1
Hormesis: principles and applications.兴奋效应:原理与应用
Homeopathy. 2015 Apr;104(2):69-82. doi: 10.1016/j.homp.2015.02.007. Epub 2015 Mar 21.
2
Mcl-1 is up regulated by prenylated coumarin, umbelliprenin in jurkat cells.在Jurkat细胞中,Mcl-1由异戊烯化香豆素伞形异戊烯基香豆素上调。
Iran J Pharm Res. 2014 Fall;13(4):1387-92.
3
Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL cell line.新疆阿魏中的伞形花内酯激活Jurkat T - CLL细胞系凋亡的内源性和外源性途径。
Avicenna J Phytomed. 2020 Jan-Feb;10(1):1-2.
4
7-Isopenthenyloxycoumarin, Arctigenin, and Hesperidin Modify Myeloid Cell Leukemia Type-1 (Mcl-1) Gene Expression by Hormesis in K562 Cell Line.7-异戊烯氧基香豆素、牛蒡子苷元与橙皮苷通过兴奋效应调节K562细胞系中髓样细胞白血病-1(Mcl-1)基因的表达。
Dose Response. 2018 Sep 11;16(3):1559325818796014. doi: 10.1177/1559325818796014. eCollection 2018 Jul-Sep.
Iran J Pharm Res. 2013 Summer;12(3):371-6.
4
Umbelliprenin Induces Apoptosis in CLL Cell Lines.伞形花内酯前体诱导慢性淋巴细胞白血病细胞系凋亡。
Iran J Pharm Res. 2012 Spring;11(2):653-9.
5
Hormetic mechanisms.胁迫机制。
Crit Rev Toxicol. 2013 Aug;43(7):580-606. doi: 10.3109/10408444.2013.808172.
6
The importance of hormesis to public health.毒物兴奋效应对于公众健康的重要性。
Environ Health Perspect. 2006 Nov;114(11):1631-5. doi: 10.1289/ehp.8606.
7
Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences.范式迷失,范式重现:毒物兴奋效应作为毒理学基础剂量反应模型的再度兴起。
Environ Pollut. 2005 Dec;138(3):379-411. doi: 10.1016/j.envpol.2004.10.001.
8
A model of two functionally antagonistic receptor populations activated by the same agonist.由同一激动剂激活的两个功能拮抗受体群体的模型。
J Theor Biol. 1977 Nov 7;69(1):101-12. doi: 10.1016/0022-5193(77)90390-3.