Institute of Frontier Medical Science, Jilin University, Changchun 130021, China.
Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
J Immunol Res. 2017;2017:6710278. doi: 10.1155/2017/6710278. Epub 2017 May 15.
Respiratory diseases, always being a threat towards the health of people all over the world, are most tightly associated with immune system. Neutrophils serve as an important component of immune defense barrier linking innate and adaptive immunity. They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential role in the pathogenesis of many respiratory diseases. However, the pathological mechanism of neutrophils remains complex and obscure. The traditional roles of neutrophils in severe asthma, chronic obstructive pulmonary diseases (COPD), pneumonia, lung cancer, pulmonary fibrosis, bronchitis, and bronchiolitis had already been reviewed. With the development of scientific research, the involvement of neutrophils in respiratory diseases is being brought to light with emerging data on neutrophil subsets, trafficking, and cell death mechanism (e.g., NETosis, apoptosis) in diseases. We reviewed all these recent studies here to provide you with the latest advances about the role of neutrophils in respiratory diseases.
呼吸系统疾病一直是全世界人民健康的威胁，与免疫系统关系最为密切。中性粒细胞作为连接先天免疫和适应性免疫的免疫防御屏障的重要组成部分，参与清除外源性病原体和内源性细胞碎片，并在许多呼吸系统疾病的发病机制中发挥重要作用。然而，中性粒细胞的病理机制仍然复杂而模糊。传统上认为中性粒细胞在重症哮喘、慢性阻塞性肺疾病（COPD）、肺炎、肺癌、肺纤维化、支气管炎和细支气管炎中的作用已经得到了研究。随着科学研究的发展，中性粒细胞在呼吸系统疾病中的作用随着关于中性粒细胞亚群、趋化和细胞死亡机制（如 NETosis、细胞凋亡）的新兴数据而逐渐被揭示。我们在这里回顾了所有这些最新研究，为您提供有关中性粒细胞在呼吸系统疾病中的作用的最新进展。
