[Vasoactive hormones and mediators in the mechanism of the development of an aphthous process in the oral mucosa].

Experiments on dogs were made to simulate aphthous process on the oral mucosa by occlusion of the common bile duct. The content of adrenaline, noradrenaline, serotonin, histamine and ascorbic acid was measured during the development of pathological process in the areas of oral mucosa tissue characterized by most frequent appearance of aphthas and in the tissue of the duodenal, small and large intestine mucosa. The magnitude of the characteristics indicated was determined 2, 6 and 12 h and 1, 3, 7 and 10 days after operation. Aphthas appeared on the 3d day. Within the first hours of the experiment there was a considerable increase in the content of noradrenaline, adrenaline and serotonin in the oral mucosa accompanied by a reduction in the histamine and ascorbic acid content. In the intestinal mucosa, shifts in the correlations between the hormones and transmitters were less pronounced. During aphthas appearance, the histamine content rose whereas other parameters decreased. The period of the reverse development was characterized by the recovery of the correlations of the hormones under study and transmitters.