Aĭrapetian G O, Veretinskaia A G
Biull Eksp Biol Med. 1985 Jul;100(7):42-3.
Aphthous lesions of the oral mucosa were simulated in dogs by common bile duct ligation. In one of the experimental groups, the animals were administered the beta-adrenoblocker obsidan 30 min before operation. Two hours after operation the regions of the oral mucosa mostly affected by aphthous lesions were examined for the content of adrenaline and noradrenaline (NA). The data obtained indicate a significant increase in the content of NA and adrenaline in the oral mucosa 2 h following operation. In animals pretreated with obsidan, the content of catecholamines remained at the level seen in the control group. Therefore, blocking the transmission of nerve impulses to the sympathetic nervous system obsidan interferes with the reflex influence from the involved organs of the abdominal cavity, thereby protecting the oral mucosa tissues from the damage-inducing action of high concentrations of NA.
通过结扎胆总管在犬身上模拟口腔黏膜的阿弗他病变。在其中一个实验组中，动物在手术前30分钟给予β-肾上腺素能阻滞剂奥布西丹。术后两小时，检查口腔黏膜中受阿弗他病变影响最严重的区域的肾上腺素和去甲肾上腺素（NA）含量。获得的数据表明，术后2小时口腔黏膜中NA和肾上腺素的含量显著增加。在用奥布西丹预处理的动物中，儿茶酚胺含量保持在对照组所见水平。因此，奥布西丹阻断神经冲动向交感神经系统的传递，干扰来自腹腔相关器官的反射影响，从而保护口腔黏膜组织免受高浓度NA的损伤作用。
