Barkovskiĭ V S, Aĭrapetian G O
Biull Eksp Biol Med. 1985 Sep;100(9):294-6.
Aphthous lesions in the oral mucosa (OM) were simulated in dog experiments by ligation of the common bile duct. In one of the experimental groups the beta-adrenoblocker propranolol was administered 30 min before surgery. Two hours after surgery the animals manifested changes in blood microcirculation of the OM. In animals treated with propranolol, the characteristics of blood microcirculation remained within normal. It is concluded that the development of aphthous lesions is preceded by functional disorders of blood microcirculation in the OM which are probably related to alterations in the neurovascular system.
在犬实验中，通过结扎胆总管模拟口腔黏膜（OM）的口疮性病变。在其中一个实验组中，在手术前30分钟给予β-肾上腺素能阻滞剂普萘洛尔。手术后两小时，动物口腔黏膜的血液微循环出现变化。在用普萘洛尔治疗的动物中，血液微循环特征保持在正常范围内。结论是，口疮性病变的发生之前口腔黏膜存在血液微循环功能障碍，这可能与神经血管系统的改变有关。
