利用斑马鱼研究调控造血干细胞自我更新和迁移的途径。
Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration.
机构信息
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
出版信息
Stem Cell Reports. 2017 Jun 6;8(6):1465-1471. doi: 10.1016/j.stemcr.2017.05.018.
Abstract
This perspective describes the usefulness of zebrafish as a model to study interaction of hematopoietic stem cells with the associated niche in vivo, explains how such interactions influence regeneration, migration, and clonality of HSCs, and defines their fate during differentiation.
摘要
本观点描述了斑马鱼作为模型研究造血干细胞与体内相关龛相互作用的有用性，解释了这种相互作用如何影响 HSCs 的再生、迁移和克隆性，并定义了它们在分化过程中的命运。
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