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聚己内酯/聚氨酯负载共轭亚油酸的制备及其抗血小板黏附作用

Fabrication of Polycaprolactone/Polyurethane Loading Conjugated Linoleic Acid and Its Antiplatelet Adhesion.

作者信息

Minh Ho Hieu, Hiep Nguyen Thi, Hai Nguyen Dai, Toi Vo Van

机构信息

Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Engineering, International University of Vietnam National Universities, Ho Chi Minh City 700000, Vietnam.

Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 Mac Dinh Chi, District 1, Ho Chi Minh City, Vietnam.

出版信息

Int J Biomater. 2017;2017:5690625. doi: 10.1155/2017/5690625. Epub 2017 May 16.

DOI:10.1155/2017/5690625
PMID:28592972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5448153/
Abstract

Polycaprolactone/polyurethane (PCL/PU) fibrous scaffold was loaded with conjugated linoleic acid (CLA) by electrospinning method to improve the hemocompatibility of the polymeric surface. Fourier Transform Infrared Spectroscopy (FT-IR) analysis and Scanning Electron Microscopy (SEM) observation were employed to characterize the chemical structure and the changing morphology of electrospun PCL/PU and PCL/PU loaded with CLA (PCL/PU-CLA) scaffolds. Platelet adhesion and whole blood clot formation tests were used to evaluate the effect of CLA on antithrombotic property of PCL/PU-CLA scaffold. Endothelial cells (EC) were also seeded on the scaffold to examine the difference in the morphology of EC layer and platelet attachment with and without the presence of CLA. SEM results showed that CLA supported the spreading and proliferation of EC and PCL/PU-CLA surface induced lower platelet adhesion as well as attachment of other blood cells compared to the PCL/PU one. These results suggest that electrospinning method can successfully combine the antiplatelet effects of CLA to improve hemocompatibility of PCL/PU scaffolds for applications in artificial blood vessels.

摘要

采用静电纺丝法将共轭亚油酸（CLA）负载于聚己内酯/聚氨酯（PCL/PU）纤维支架上，以改善聚合物表面的血液相容性。利用傅里叶变换红外光谱（FT-IR）分析和扫描电子显微镜（SEM）观察对静电纺丝PCL/PU以及负载CLA的PCL/PU（PCL/PU-CLA）支架的化学结构和形态变化进行表征。通过血小板黏附试验和全血凝血试验评估CLA对PCL/PU-CLA支架抗血栓性能的影响。还将内皮细胞（EC）接种在支架上，以检查有无CLA时EC层形态和血小板黏附的差异。SEM结果表明，与PCL/PU表面相比，CLA促进了EC的铺展和增殖，PCL/PU-CLA表面诱导的血小板黏附以及其他血细胞的黏附较少。这些结果表明，静电纺丝法可以成功地结合CLA的抗血小板作用，提高PCL/PU支架在人造血管应用中的血液相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/5864de058e33/IJBM2017-5690625.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/5b2f75f454ca/IJBM2017-5690625.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/921590493514/IJBM2017-5690625.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/8260c0c14da3/IJBM2017-5690625.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/25ef387d05f3/IJBM2017-5690625.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/7b9056c5b747/IJBM2017-5690625.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/5864de058e33/IJBM2017-5690625.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/5b2f75f454ca/IJBM2017-5690625.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/921590493514/IJBM2017-5690625.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/8260c0c14da3/IJBM2017-5690625.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/25ef387d05f3/IJBM2017-5690625.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/7b9056c5b747/IJBM2017-5690625.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b8/5448153/5864de058e33/IJBM2017-5690625.006.jpg

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本文引用的文献

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J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):189-97. doi: 10.4103/0974-2077.150734.
2
Overview of the coagulation system.凝血系统概述。
Indian J Anaesth. 2014 Sep;58(5):515-23. doi: 10.4103/0019-5049.144643.
3
Polyurethane-based scaffolds for myocardial tissue engineering.基于聚氨酯的心肌组织工程支架。
Interface Focus. 2014 Feb 6;4(1):20130045. doi: 10.1098/rsfs.2013.0045.
4
A hybrid electrospun PU/PCL scaffold satisfied the requirements of blood vessel prosthesis in terms of mechanical properties, pore size, and biocompatibility.一种混合电纺的聚氨酯/聚己内酯支架在机械性能、孔径和生物相容性方面满足了血管假体的要求。
J Biomater Sci Polym Ed. 2013;24(14):1692-706. doi: 10.1080/09205063.2013.792642. Epub 2013 Apr 29.
5
Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges.血管组织工程：功能需求、进展与未来挑战
Cardiovasc Eng Technol. 2011 Sep 1;2(3):137-148. doi: 10.1007/s13239-011-0049-3.
6
Evaluation of in situ albumin binding surfaces: a study of protein adsorption and platelet adhesion.原位白蛋白结合表面的评估：蛋白质吸附和血小板黏附的研究。
J Mater Sci Mater Med. 2011 Jan;22(1):137-49. doi: 10.1007/s10856-010-4169-3. Epub 2010 Dec 1.
7
Poly(dimethyl siloxane) surface modification by low pressure plasma to improve its characteristics towards biomedical applications.采用低压等离子体对聚二甲基硅氧烷表面进行改性，以改善其在生物医学应用方面的特性。
Colloids Surf B Biointerfaces. 2010 Nov 1;81(1):20-6. doi: 10.1016/j.colsurfb.2010.06.014. Epub 2010 Jun 25.
8
Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility.PLGA/PCL 共混物的静电纺丝及其生物相容性在组织工程中的应用。
J Mater Sci Mater Med. 2010 Jun;21(6):1969-78. doi: 10.1007/s10856-010-4048-y. Epub 2010 Mar 16.
9
The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility.将肝素共价固定在 316L 不锈钢上的脉冲等离子聚合烯丙胺膜及其对血液相容性的影响。
Biomaterials. 2010 Mar;31(8):2072-83. doi: 10.1016/j.biomaterials.2009.11.091.
10
Encapsulation of proteins in poly(L-lactide-co-caprolactone) fibers by emulsion electrospinning.乳液电纺法包埋聚（L-丙交酯-共-己内酯）纤维中的蛋白质。
Colloids Surf B Biointerfaces. 2010 Feb 1;75(2):418-24. doi: 10.1016/j.colsurfb.2009.09.014. Epub 2009 Sep 22.