Guler Ezgi, Ozgen Burce, Mut Melike, Soylemezoglu Figen, Oguz Kader Karli
Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Department of Neurosurgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
J Neurol Surg B Skull Base. 2017 Jun;78(3):256-265. doi: 10.1055/s-0036-1597824. Epub 2017 Jan 23.
To determine the use of diffusion-weighted imaging (DWI) in the pre- and posttreatment evaluation of skull base chordomas. Retrospective study. Tertiary care university hospital. In total, 17 patients with histopathological diagnosis of chordoma who had magnetic resonance (MR) imaging and DWI were evaluated. Of them, 13 patients had posttreatment MR imaging including DWI. Three apparent diffusion coefficient (ADC) values were obtained from tumor, and an ADC value was measured from pons for the purpose of normalization. ADC values of the subtypes of chordomas (typical and chondroid chordomas) were compared. Ten (59%) masses had increased signal on trace DWI at pretreatment evaluation. The mean ADC /ADC was calculated as 1.55 ± 0.44. The mean ADC values of typical and chondroid chordomas were 1.26 ± 0.29 × 10 mm /s and 0.99 ± 0.46 × 10 mm /s, respectively. There was no statistically significant difference between ADC values of the subtypes ( > 0.05). For posttreatment evaluation, DWI enabled detection of residual tumor in the majority (85%) of cases. DWI is useful in diagnosis and posttreatment evaluation of skull base chordomas. However, ADC values in our series did not distinguish the subtypes of chordomas.
确定扩散加权成像（DWI）在颅底脊索瘤治疗前后评估中的应用。 回顾性研究。 三级医疗大学医院。 总共评估了17例经组织病理学诊断为脊索瘤且进行了磁共振（MR）成像和DWI检查的患者。其中，13例患者进行了包括DWI的治疗后MR成像。 从肿瘤中获取三个表观扩散系数（ADC）值，并从脑桥测量一个ADC值用于标准化目的。比较了脊索瘤亚型（典型和软骨样脊索瘤）的ADC值。 在治疗前评估中，10个（59%）肿块在DWI追踪成像上信号增强。计算出平均ADC /ADC为1.55±0.44。典型和软骨样脊索瘤的平均ADC值分别为1.26±0.29×10 mm /s和0.99±0.46×10 mm /s。各亚型的ADC值之间无统计学显著差异（>0.05）。对于治疗后评估，DWI能够在大多数（85%）病例中检测到残留肿瘤。 DWI在颅底脊索瘤的诊断和治疗后评估中有用。然而，我们系列研究中的ADC值未能区分脊索瘤的亚型。
