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腹腔镜袖状胃切除术后的胃食管反流、袖状扩张及巴雷特食管:长期随访

Reflux, Sleeve Dilation, and Barrett's Esophagus after Laparoscopic Sleeve Gastrectomy: Long-Term Follow-Up.

作者信息

Felsenreich Daniel Moritz, Kefurt Ronald, Schermann Martin, Beckerhinn Philipp, Kristo Ivan, Krebs Michael, Prager Gerhard, Langer Felix B

机构信息

Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Department for Surgery, Hospital Rudolfsstiftung, Vienna, Austria.

出版信息

Obes Surg. 2017 Dec;27(12):3092-3101. doi: 10.1007/s11695-017-2748-9.

Abstract

BACKGROUND

Laparoscopic sleeve gastrectomy (SG) has become the most frequently performed bariatric procedure worldwide. De novo reflux might impact patients' quality of life, requiring lifelong proton pump inhibitor medication. It also increases the risk of esophagitis and formation of Barrett's metaplasia. Besides weight regain, gastroesophageal reflux disease (GERD) is the most common reason for conversion to Roux-en-Y gastric bypass.

METHODS

We performed 24-h pH metries, manometries, gastroscopies, and questionnaires focusing on reflux (GIQLI, RSI) in SG patients with a follow-up of more than 10 years who did not suffer from symptomatic reflux or hiatal hernia preoperatively.

RESULTS

From a total of 53 patients, ten patients after adjustable gastric banding were excluded. From the remaining 43, six patients (14.0%) were converted to RYGB due to intractable reflux over a period of 130 months. Ten out of the remaining non-converted patients (n = 26) also suffered from symptomatic reflux. Gastroscopies revealed de novo hiatal hernias in 45% of the patients and Barrett's metaplasia in 15%. SG patients suffering from symptomatic reflux scored significantly higher in the RSI (p = 0.04) and significantly lower in the GIQLI (p = 0.02) questionnaire.

CONCLUSIONS

This study shows a high incidence of Barrett's esophagus and hiatal hernias at more than 10 years after SG. Its results therefore suggest maintaining pre-existing large hiatal hernia, GERD, and Barrett's esophagus as relative contraindications to SG. The limitations of this study-its small sample size as well as the fact that it was based on early experience with SG-make drawing any general conclusions about this procedure difficult.

摘要

背景

腹腔镜袖状胃切除术(SG)已成为全球最常施行的减肥手术。新发反流可能会影响患者的生活质量,需要终身服用质子泵抑制剂。这也增加了食管炎和巴雷特化生形成的风险。除体重反弹外,胃食管反流病(GERD)是转为 Roux-en-Y 胃旁路术最常见的原因。

方法

我们对术前无反流症状或食管裂孔疝的 SG 患者进行了 24 小时食管 pH 监测、食管测压、胃镜检查,并使用了针对反流的问卷(GIQLI、RSI),随访时间超过 10 年。

结果

在总共 53 例患者中,排除了 10 例接受可调节胃束带术的患者。在其余 43 例患者中,6 例(14.0%)因难治性反流在 130 个月内转为 RYGB。其余未转换的患者中有 10 例(n = 26)也有症状性反流。胃镜检查显示 45%的患者有新发食管裂孔疝,15%的患者有巴雷特化生。有症状性反流的 SG 患者在 RSI 问卷中的得分显著更高(p = 0.04),在 GIQLI 问卷中的得分显著更低(p = 0.02)。

结论

本研究显示 SG 术后 10 年以上巴雷特食管和食管裂孔疝的发生率较高。因此,其结果提示将既往存在的大食管裂孔疝、GERD 和巴雷特食管作为 SG 的相对禁忌证。本研究的局限性——样本量小以及基于 SG 的早期经验——使得难以就此手术得出任何一般性结论。

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