Song Chao, Li Le, Zhang Cong, Kamira Barry, Qiu Liping, Fan Limin, Wu Wei, Meng Shunlong, Hu Gengdong, Chen Jiazhang
Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, People's Republic of China.
Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environments Factors (Wuxi), Ministry of Agriculture, Wuxi, People's Republic of China.
Environ Sci Pollut Res Int. 2017 Jul;24(21):17493-17499. doi: 10.1007/s11356-017-9442-2. Epub 2017 Jun 7.
As the most important fishery medicines, sulfonamides are widely used to prevent diseases caused by pathogens in aquaculture. However, relatively little is known about the residues and dietary risks associated with cultured fish around Tai Lake. In the present study, a sampling strategy for a complete aquaculture period was conducted. Specifically, 12 selected sulfonamide antibiotics were measured among 116 fish samples recruited from four sampling periods, four species, four areas, and 18 fish ponds. All 12 antibiotics were detected at detection frequencies of 4.31-28.45%. Total sulfonamides were detected in 77.59% of the fish samples, with 57.76% of fish samples containing from 0.1 to 10 μg kg. Sulfadiazine (SDZ), sulfamethoxazole (SMZ), sulfamethazine (SDD), and sulfamonomethoxine (SMM) were the main types of antibiotics used, and these were present at high concentrations (>100 μg kg) with high occurrences, especially in the middle of the aquaculture season. Dietary assessment showed that residual antibiotics in all fish that were being sent to market were far below the maximum residue limit (MRL) of total sulfonamides and that there was almost no risk associated with fish consumption. The results of the present study will facilitate development of effective measures to produce safe aquatic products and meaningful suggestions for consuming aquatic products.
作为最重要的水产药物，磺胺类药物被广泛用于预防水产养殖中由病原体引起的疾病。然而，对于太湖周边养殖鱼类中磺胺类药物的残留情况及膳食风险，人们了解相对较少。在本研究中，实施了一个涵盖完整养殖周期的采样策略。具体而言，在从四个采样时期、四个物种、四个区域和18个鱼塘采集的116份鱼类样本中，测定了12种选定的磺胺类抗生素。所有12种抗生素的检出频率为4.31% - 28.45%。77.59%的鱼类样本中检测到了总磺胺类药物，其中57.76%的鱼类样本中总磺胺类药物含量为0.1至10 μg/kg。磺胺嘧啶（SDZ）、磺胺甲恶唑（SMZ）、磺胺二甲嘧啶（SDD）和磺胺间甲氧嘧啶（SMM）是主要使用的抗生素类型，这些抗生素在高浓度（>100 μg/kg）下出现频率较高，尤其是在养殖季节中期。膳食评估表明，所有上市鱼类中的残留抗生素均远低于总磺胺类药物的最大残留限量（MRL），食用鱼类几乎不存在风险。本研究结果将有助于制定生产安全水产品的有效措施，并为食用水产品提供有意义的建议。
