Am J Epidemiol. 2018 Apr 1;187(4):639-646. doi: 10.1093/aje/kwx203.
This article examines how the epidemiologic transition and the reduction of the urban mortality penalty gave rise to the current mortality regime of the United States and demonstrates how the 1918 influenza pandemic signaled its advent. This article approaches those issues through the analysis of urban-rural mortality differentials from 1890 to 1930. Until 1910, infectious diseases dwarfed degenerative diseases in leading causes of death, and generally, the more urban the location was, the higher infectious disease and overall death rates were-a direct relationship. But by 1930, degenerative diseases had eclipsed infectious diseases, and infectious disease mortality had ceased to differ between cities and rural areas. The 1918 influenza pandemic broke out toward the end of these changes, and the larger the city was, the lower influenza and overall death rates were in that year-an inverse relationship. Such gradations characterized a new mortality regime emerging in the late 1910s and foreshadowed urban-rural mortality differentials in 1930 among persons aged 45 years or older, the group whose high rates of degenerative disease death would symbolize that regime. Thus, intertwined changes in the late 19th and early 20th centuries-a shift in leading causes of death from infectious diseases to degenerative diseases and a concomitant shift from a direct relationship to an inverse relationship between urban environment and mortality-produced the current mortality regime of the United States.
本文考察了流行病学转变和城市死亡率下降如何导致美国当前的死亡率模式,并展示了 1918 年流感大流行如何标志着其到来。本文通过分析 1890 年至 1930 年的城乡死亡率差异来探讨这些问题。直到 1910 年,传染病在导致死亡的主要原因中仍然超过退行性疾病,而且通常城市的位置越高,传染病和总死亡率就越高——这是一种直接的关系。但到 1930 年,退行性疾病已经超过了传染病,城市和农村地区的传染病死亡率不再有差异。1918 年流感大流行正是在这些变化的末期爆发的,城市越大,那年的流感和总死亡率就越低——这是一种反比关系。这种渐变标志着 20 世纪 10 年代末出现的一种新的死亡率模式,并预示着 1930 年 45 岁及以上人群的城乡死亡率差异,这一年龄组退行性疾病死亡率较高,将成为该模式的象征。因此,19 世纪末和 20 世纪初的交织变化——导致死亡的主要原因从传染病转变为退行性疾病,以及城市环境与死亡率之间的关系从直接关系转变为反比关系——产生了美国当前的死亡率模式。