精神分裂症患者的癌症死亡率：系统评价和荟萃分析。
Cancer mortality in patients with schizophrenia: systematic review and meta-analysis.
机构信息
Chuanjun Zhuo, MD, PhD, Department of Psychiatry, Wenzhou Seventh people's Hospital, Wenzhou, Zhejiang and Department of Psychiatry, Tianjin Anding Hospital, Hexi District and Dongli District, Tianjin, China; Ran Tao, MD, Department of Psychiatry, Chinese PLA (people's Liberation Army) Hospital, Dongzhimen, Dongcheng District, Beijing; Ronghuan Jiang, MD, Department of Psychiatry, Chinese PLA (People's Liberation Army) Medical School, Haidian District, Beijing; Xiaodong Lin, MD, Department of Psychiatry, Wenzhou Seventh people's Hospital, Wenzhou, Zhejiang, China; Mingjing Shao, MD, Department of Psychiatry, Chinese PLA (People's Liberation Army) Medical School, Haidian District, Beijing, China
Chuanjun Zhuo, MD, PhD, Department of Psychiatry, Wenzhou Seventh people's Hospital, Wenzhou, Zhejiang and Department of Psychiatry, Tianjin Anding Hospital, Hexi District and Dongli District, Tianjin, China; Ran Tao, MD, Department of Psychiatry, Chinese PLA (people's Liberation Army) Hospital, Dongzhimen, Dongcheng District, Beijing; Ronghuan Jiang, MD, Department of Psychiatry, Chinese PLA (People's Liberation Army) Medical School, Haidian District, Beijing; Xiaodong Lin, MD, Department of Psychiatry, Wenzhou Seventh people's Hospital, Wenzhou, Zhejiang, China; Mingjing Shao, MD, Department of Psychiatry, Chinese PLA (People's Liberation Army) Medical School, Haidian District, Beijing, China.
出版信息
Br J Psychiatry. 2017 Jul;211(1):7-13. doi: 10.1192/bjp.bp.116.195776. Epub 2017 Jun 8.
Previous studies have reported conflicting results on the association between schizophrenia and cancer mortality.To summarise available evidence and quantify the association between schizophrenia and cancer mortality using meta-analysis.We systematically searched literature in the PubMed and Embase databases. Risk estimates and 95% confidence intervals reported in individual studies were pooled using the DerSimonian-Laird random-effects model.We included 19 studies in the meta-analysis. Among them, 15 studies reported standardised mortality ratios (SMRs) comparing patients with schizophrenia with the general population, and the pooled SMR was 1.40 (95% CI 1.29-1.52, < 0.001). The other four studies reported hazard ratios (HRs) comparing individuals with schizophrenia with those without schizophrenia; the pooled HR was 1.51 (95% CI 1.13-2.03, = 0.006).Patients with schizophrenia are at a significantly increased risk of cancer mortality compared with the general population or individuals without schizophrenia.
先前的研究报告称精神分裂症与癌症死亡率之间的关联存在矛盾的结果。为了总结现有证据并使用荟萃分析量化精神分裂症与癌症死亡率之间的关联，我们系统地检索了 PubMed 和 Embase 数据库中的文献。使用 DerSimonian-Laird 随机效应模型对个体研究中报告的风险估计值和 95%置信区间进行了汇总。我们将 19 项研究纳入荟萃分析。其中，15 项研究报告了比较精神分裂症患者与普通人群的标准化死亡率比 (SMR)，汇总的 SMR 为 1.40（95%CI 1.29-1.52，<0.001）。另外四项研究报告了比较精神分裂症患者和非精神分裂症患者的风险比 (HR)；汇总的 HR 为 1.51（95%CI 1.13-2.03，=0.006）。与普通人群或非精神分裂症患者相比，精神分裂症患者的癌症死亡率显著增加。
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