Rishi Gautam, Subramaniam V Nathan
Liver Disease and Iron Disorders Research Group, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Liver Disease and Iron Disorders Research Group, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia
Am J Physiol Gastrointest Liver Physiol. 2017 Sep 1;313(3):G157-G165. doi: 10.1152/ajpgi.00004.2017. Epub 2017 Jun 8.
The liver is one of the largest and most functionally diverse organs in the human body. In addition to roles in detoxification of xenobiotics, digestion, synthesis of important plasma proteins, gluconeogenesis, lipid metabolism, and storage, the liver also plays a significant role in iron homeostasis. Apart from being the storage site for excess body iron, it also plays a vital role in regulating the amount of iron released into the blood by enterocytes and macrophages. Since iron is essential for many important physiological and molecular processes, it increases the importance of liver in the proper functioning of the body's metabolism. This hepatic iron-regulatory function can be attributed to the expression of many liver-specific or liver-enriched proteins, all of which play an important role in the regulation of iron homeostasis. This review focuses on these proteins and their known roles in the regulation of body iron metabolism.
肝脏是人体最大且功能最多样化的器官之一。除了在异源生物解毒、消化、重要血浆蛋白合成、糖异生、脂质代谢和储存方面发挥作用外，肝脏在铁稳态中也起着重要作用。它不仅是体内多余铁的储存部位，还在调节肠上皮细胞和巨噬细胞释放到血液中的铁量方面发挥着至关重要的作用。由于铁对许多重要的生理和分子过程至关重要，这增加了肝脏在身体新陈代谢正常运作中的重要性。这种肝脏铁调节功能可归因于许多肝脏特异性或肝脏富集蛋白的表达，所有这些蛋白在铁稳态调节中都起着重要作用。本综述重点关注这些蛋白及其在调节体内铁代谢中的已知作用。
