前列腺素可能并不介导生长抑素对大鼠胃酸分泌的抑制作用。

Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat.

作者信息

Mogard M H, Kauffman G L, Pehlevanian M, Golanska E, Elashoff J D, Walsh J H

出版信息

Regul Pept. 1985 Mar;10(2-3):231-6. doi: 10.1016/0167-0115(85)90017-5.

Abstract

The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Prostaglandin synthesis inhibition (less than 90%) by indomethacin was verified with PGE2-generation assay on gastric mucosal tissue. In both conscious and anesthetized rats somatostatin significantly inhibited the stimulated acid output in the control and indomethacin pretreated groups. The present findings do not support a role for prostaglandins in the inhibition of gastric acid secretion by somatostatin in the rat.

摘要

在清醒和麻醉大鼠中评估了前列腺素作为生长抑素对胃酸分泌抑制作用介质的作用。在有或没有吲哚美辛预处理的情况下，测定了生长抑素对氨甲酰甲胆碱刺激的胃酸分泌的影响。通过对胃黏膜组织进行前列腺素E2生成测定，证实了吲哚美辛对前列腺素合成的抑制作用（小于90%）。在清醒和麻醉大鼠中，生长抑素在对照组和吲哚美辛预处理组中均显著抑制了刺激后的酸分泌。目前的研究结果不支持前列腺素在大鼠生长抑素抑制胃酸分泌中起作用。