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前列腺素是否参与了生长抑素介导的猫胃分泌抑制过程？

Are prostaglandins involved in somatostatin mediated inhibition of gastric secretion in the cat?

作者信息

Albinus M, Frisch G

出版信息

Agents Actions. 1986 Apr;18(1-2):205-9. doi: 10.1007/BF01988022.

DOI:10.1007/BF01988022
PMID:2873723
Abstract

The role of prostaglandins in somatostatin mediated gastric inhibitory effects has been investigated in conscious cats. The effect of somatostatin on pentagastrin-, insulin- and histamine plus bethanechol-stimulated gastric acid and pepsin secretion was determined with and without indomethacin pretreatment. Somatostatin significantly inhibited acid and pepsin secretion and this effect was not diminished by cyclo-oxygenase inhibition. It is concluded that there is no evidence that endogenous prostaglandins mediate the inhibitory effects of somatostatin on gastric acid and pepsin secretion in the cat.

摘要

在清醒猫身上研究了前列腺素在生长抑素介导的胃抑制作用中的作用。在给予和不给予吲哚美辛预处理的情况下，测定了生长抑素对五肽胃泌素、胰岛素以及组胺加氨甲酰甲胆碱刺激的胃酸和胃蛋白酶分泌的影响。生长抑素显著抑制胃酸和胃蛋白酶分泌，且这种作用不会因环氧化酶抑制而减弱。得出的结论是，没有证据表明内源性前列腺素介导生长抑素对猫胃酸和胃蛋白酶分泌的抑制作用。

相似文献

1
Are prostaglandins involved in somatostatin mediated inhibition of gastric secretion in the cat?前列腺素是否参与了生长抑素介导的猫胃分泌抑制过程？
Agents Actions. 1986 Apr;18(1-2):205-9. doi: 10.1007/BF01988022.
2
Evidence against prostaglandin-mediation of somatostatin-inhibition of gastric secretions.反对前列腺素介导生长抑素抑制胃酸分泌的证据。
Regul Pept. 1985 Mar;10(2-3):259-66. doi: 10.1016/0167-0115(85)90020-5.
3
Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat.前列腺素可能并不介导生长抑素对大鼠胃酸分泌的抑制作用。
Regul Pept. 1985 Mar;10(2-3):231-6. doi: 10.1016/0167-0115(85)90017-5.
4
Somatostatin increases the ratio between gastric mucosal blood flow and gastric acid and pepsin secretion in dogs.
Scand J Gastroenterol. 1986 Mar;21(2):215-20. doi: 10.3109/00365528609034649.
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The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.生长抑素和甲硫咪特对清醒猫中五肽胃泌素刺激的胃酸和胃蛋白酶分泌快速耐受的影响。
J Physiol. 1977 Apr;266(3):801-17. doi: 10.1113/jphysiol.1977.sp011794.
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The mechanism of inhibitory action of secretin on gastric acid secretion in conscious rats.促胰液素对清醒大鼠胃酸分泌的抑制作用机制
J Physiol. 1995 Oct 15;488 ( Pt 2)(Pt 2):501-8. doi: 10.1113/jphysiol.1995.sp020984.
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Somatostatin effects on gastric electrolytes and pepsin in dogs with various secretory stimuli.生长抑素对不同分泌刺激状态下犬胃电解质及胃蛋白酶的影响。
J Pharmacol Exp Ther. 1987 Nov;243(2):501-6.
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Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat.清醒猫体内刺激后的胃前列腺素分泌以及前列腺素合成酶抑制作用的效果
J Physiol. 1981 Aug;317:21-8. doi: 10.1113/jphysiol.1981.sp013811.
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Divergent effects of bombesin and bethanechol on stimulated gastric secretion in duodenal ulcer and in normal men.蛙皮素和氨甲酰甲胆碱对十二指肠溃疡患者及正常人刺激胃酸分泌的不同作用。
Gastroenterology. 1987 Jun;92(6):1926-33. doi: 10.1016/0016-5085(87)90626-3.
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[Effects of somatostatin and its analog on gastric secretion. An application of the secretagogues to gastric secretion].[生长抑素及其类似物对胃酸分泌的影响。促分泌素在胃酸分泌中的应用]
Nihon Yakurigaku Zasshi. 1985 Sep;86(3):189-95. doi: 10.1254/fpj.86.189.

本文引用的文献

1
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents.
Prostaglandins. 1981;21 Suppl:113-8. doi: 10.1016/0090-6980(81)90126-x.
2
Action of MDL 646, a new synthetic prostaglandin, on gastric acid secretion of some experimental animals.
Res Commun Chem Pathol Pharmacol. 1983 Feb;39(2):211-28.
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Specific inhibition by prostaglandins E2 and I2 of histamine-stimulated [14C]aminopyrine accumulation and cyclic adenosine monophosphate generation by isolated canine parietal cells.前列腺素E2和I2对组胺刺激的犬离体壁细胞[14C]氨基比林蓄积及环磷酸腺苷生成的特异性抑制作用。
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Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat.前列腺素介导生长抑素对大鼠胃酸分泌的抑制作用。
Science. 1983 Jan 21;219(4582):301-3. doi: 10.1126/science.6129701.
5
Evidence against prostaglandin-mediation of somatostatin-inhibition of gastric secretions.反对前列腺素介导生长抑素抑制胃酸分泌的证据。
Regul Pept. 1985 Mar;10(2-3):259-66. doi: 10.1016/0167-0115(85)90020-5.
6
Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat.前列腺素可能并不介导生长抑素对大鼠胃酸分泌的抑制作用。
Regul Pept. 1985 Mar;10(2-3):231-6. doi: 10.1016/0167-0115(85)90017-5.
7
Somatostatin binding sites in cytosolic fraction isolated from rabbit antral and fundic gastric mucosa.
Regul Pept. 1985 Mar;10(2-3):207-15. doi: 10.1016/0167-0115(85)90015-1.
8
Comparison of the inhibition of histamine- and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat.生长抑素对猫组胺和五肽胃泌素刺激胃酸分泌的抑制作用比较。
Agents Actions. 1977 Dec;7(5-6):501-6. doi: 10.1007/BF02111121.
9
Somatostatin and the stomach: exocrine and endocrine aspects.生长抑素与胃：外分泌和内分泌方面。
Metabolism. 1978 Sep;27(9 Suppl 1):1309-15. doi: 10.1016/0026-0495(78)90064-1.
10
Exogenous prostaglandins and gastric secretion in the cat.猫体内的外源性前列腺素与胃液分泌
J Physiol. 1978 May;278:441-50. doi: 10.1113/jphysiol.1978.sp012315.