Ikeda Tetsuya, Shimizu Kimiya, Igarashi Akihito, Kasahara Sumie, Kamiya Kazutaka
Department of Ophthalmology, University of Kitasato School of Medicine, Kanagawa, Japan.
Biomed Res Int. 2017;2017:9391436. doi: 10.1155/2017/9391436. Epub 2017 May 17.
To assess the long-term clinical outcomes of conventional laser in situ keratomileusis (LASIK) for moderate to high myopia.
We retrospectively examined sixty-eight eyes of 37 consecutive patients who underwent conventional LASIK for the correction of myopia (-3.00 to -12.75 diopters (D)). At 3 months and 1, 4, 8, and 12 years postoperatively, we assessed the safety, efficacy, predictability, stability, mean keratometry, central corneal thickness, and adverse events.
The safety and efficacy indices were 0.82 ± 0.29 and 0.67 ± 0.37, respectively, 12 years postoperatively. At 12 years, 53% and 75% of the eyes were within 0.5 and 1.0 D, respectively, of the targeted correction. Manifest refraction changes of -0.74 ± 0.99 D occurred from 3 months to 12 years after LASIK ( < 0.001). We found a significant correlation of refractive regression with the changes in keratometric readings from 3 months to 12 years postoperatively (Pearson correlation coefficient, = -0.28, = 0.02), but not with the changes in central corneal thickness ( = -0.08, = 0.63). No vision-threatening complications occurred in any case.
Conventional LASIK offered good safety outcomes during the 12-year observation period. However, the efficacy and the predictability gradually decreased with time owing to myopic regression in relation to corneal steepening.
评估传统准分子原位角膜磨镶术（LASIK）治疗中高度近视的长期临床效果。
我们回顾性研究了37例连续患者的68只眼睛，这些患者接受了传统LASIK手术以矫正近视（-3.00至-12.75屈光度（D））。在术后3个月以及1、4、8和12年，我们评估了安全性、有效性、可预测性、稳定性、平均角膜曲率、中央角膜厚度和不良事件。
术后12年，安全性和有效性指数分别为0.82±0.29和0.67±0.37。在12年时，分别有53%和75%的眼睛矫正度数在目标矫正度数的0.5 D和1.0 D范围内。LASIK术后3个月至12年出现的明显屈光变化为-0.74±0.99 D（P<0.001）。我们发现屈光回退与术后3个月至12年角膜曲率读数的变化存在显著相关性（Pearson相关系数，r = -0.28，P = 0.02），但与中央角膜厚度的变化无关（r = -0.08，P = 0.63）。所有病例均未发生威胁视力的并发症。
在12年的观察期内，传统LASIK手术具有良好的安全性。然而，由于近视回退导致角膜变陡，其有效性和可预测性随时间逐渐降低。
