Botvinkin A D, Nikiforova T A, Sidorov G N
Acta Virol. 1985 Jan;29(1):44-50.
Experiments carried out in different seasons with different strains of rabies virus have shown that hibernation prolonged the incubation period in sousliks (Citellus major Pall.). Mean survival of the animals infected during the active period was 32 days, while during hibernation it was 147.3 days (P less than 0.05), in some cases up to 251 days. The virus was isolated from and/or detected by fluorescent antibody test in 50% of cases in the brown fat and in some cases in the salivary glands and visceral organs. The brown fat biopsy allowed to detect the virus not earlier than 6 days before death. We propose to use heterothermal rodents for the study of mechanism of rabies virus persistence and suggest that these animals might represent a natural reservoir for rabies.
在不同季节对不同毒株的狂犬病病毒进行的实验表明，冬眠延长了黄鼠（Citellus major Pall.）的潜伏期。活跃期感染病毒的动物平均存活32天，而冬眠期感染的动物平均存活147.3天（P<0.05），在某些情况下长达251天。在50%的病例中，通过荧光抗体试验从棕色脂肪中分离出病毒和/或检测到病毒，在某些情况下在唾液腺和内脏器官中也检测到病毒。棕色脂肪活检最早在死亡前6天才能检测到病毒。我们建议使用变温啮齿动物来研究狂犬病病毒持续存在的机制，并认为这些动物可能是狂犬病的天然宿主。
