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心血管疾病和神经系统疾病及其与幽门螺杆菌感染的关联——综述

Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview.

作者信息

Pădureanu Vlad, Dop Dalia, Caragea Daniel Cosmin, Rădulescu Dumitru, Pădureanu Rodica, Forțofoiu Mircea-Cătălin

机构信息

Department of Internal Medicine, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania.

Department of Pediatrics, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania.

出版信息

Diagnostics (Basel). 2024 Aug 15;14(16):1781. doi: 10.3390/diagnostics14161781.

Abstract

This article investigates the link between () infection and cardiovascular and neurological disorders. Recent research suggests that may play a role in cardiovascular diseases like atherosclerosis, myocardial infarction, and stroke, as well as neurological diseases including Alzheimer's disease, multiple sclerosis, and Parkinson's disease. Cardiovascular Diseases: induces endothelial dysfunction and chronic inflammation, promoting atherosclerotic plaque formation and other cardiac complications. High infection prevalence in cardiovascular patients implies that systemic inflammation from accelerates disease progression. Eradication therapies combined with anti-inflammatory and lipid-lowering treatments may reduce cardiovascular risk. Neurological Diseases: may contribute to Alzheimer's, multiple sclerosis, and Parkinson's through systemic inflammation, neuroinflammation, and autoimmune responses. Increased infection prevalence in these patients suggests bacterial involvement in disease pathogenesis. The eradication of could reduce neuroinflammation and improve outcomes. Discussions and Future Research: Managing infection in clinical practice could impact public health and treatment approaches. Further research is needed to clarify these relationships. Longitudinal and mechanistic studies are essential to fully understand 's role in these conditions. Conclusions: infection is a potential risk factor for various cardiovascular and neurological conditions. Additional research is critical for developing effective prevention and treatment strategies. Targeted therapies, including eradication combined with anti-inflammatory treatments, could improve clinical outcomes. These findings highlight the need for an integrated clinical approach to include evaluation and treatment.

摘要

本文研究了()感染与心血管和神经系统疾病之间的联系。最近的研究表明,()可能在动脉粥样硬化、心肌梗死和中风等心血管疾病以及阿尔茨海默病、多发性硬化症和帕金森病等神经系统疾病中发挥作用。心血管疾病:()会导致内皮功能障碍和慢性炎症,促进动脉粥样硬化斑块形成和其他心脏并发症。心血管疾病患者中()感染率较高,这意味着()引起的全身炎症会加速疾病进展。根除疗法与抗炎和降脂治疗相结合可能会降低心血管风险。神经系统疾病:()可能通过全身炎症、神经炎症和自身免疫反应导致阿尔茨海默病、多发性硬化症和帕金森病。这些患者中感染率增加表明细菌参与了疾病发病机制。根除()可以减轻神经炎症并改善治疗结果。讨论与未来研究:在临床实践中控制()感染可能会影响公共卫生和治疗方法。需要进一步研究来阐明这些关系。纵向研究和机制研究对于全面了解()在这些疾病中的作用至关重要。结论:()感染是各种心血管和神经系统疾病的潜在危险因素。更多研究对于制定有效的预防和治疗策略至关重要。包括根除()并结合抗炎治疗在内的靶向治疗可以改善临床结果。这些发现凸显了采用综合临床方法进行()评估和治疗的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35db/11353373/e9c4ab4eceb5/diagnostics-14-01781-g001.jpg

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