木霉菌素C - E，由一种海洋海绵来源真菌产生的具有稠合6-5-6-6环系的新型二萜类化合物。
Trichodermanins C-E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus.
作者信息
Yamada Takeshi, Suzue Mayo, Arai Takanobu, Kikuchi Takashi, Tanaka Reiko
机构信息
Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, Japan.
出版信息
Mar Drugs. 2017 Jun 9;15(6):169. doi: 10.3390/md15060169.
Trichodermanins C-E (-), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus OUPS-111D-4 separated from a piece of a marine sponge , and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher's method. In addition, inhibited the growth of cancer cell lines potently.
从一块海洋海绵分离出的真菌OUPS-111D-4中分离得到了具有罕见稠合6-5-6-6环系的新二萜类化合物木霉菌素C-E（-），并通过红外光谱、质谱、高分辨快原子轰击质谱和核磁共振光谱等光谱分析确定了这些化合物的化学结构。我们应用改良的莫舍尔方法确定了它们的绝对立体结构。此外，它们能有效抑制癌细胞系的生长。
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