一种来自海绵的真菌菌株产生的细胞毒性物质：物理化学性质和结构
Cytotoxic substances produced by a fungal strain from a sponge: physico-chemical properties and structures.
作者信息
Amagata T, Usami Y, Minoura K, Ito T, Numata A
机构信息
Osaka University of Pharmaceutical Sciences, Japan.
出版信息
J Antibiot (Tokyo). 1998 Jan;51(1):33-40. doi: 10.7164/antibiotics.51.33.
PMID:9531985
Abstract
Five novel metabolites, trichodenones A-C (1-3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 1-3 exhibited significant cytotoxicity against cultured P388 cells.
摘要
从最初从海绵冈村软海绵中分离出的哈茨木霉菌株OUPS-N115的培养液中，分离出了5种新的代谢产物，即木霉烯酮A-C（1-3）、哈茨内酯A（4）和B（5），以及已知的R-甲羟戊酸内酯（6）。它们的结构已通过光谱证据得以阐明。其中，1-3对培养的P388细胞表现出显著的细胞毒性。
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