Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.
School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, P. R. China.
Chem Biodivers. 2020 Apr;17(4):e2000036. doi: 10.1002/cbdv.202000036. Epub 2020 Mar 30.
Three new cadinane sesquiterpenes, trichodermaloids A (1), B (2), and C (5) were isolated from a symbiotic fungus Trichoderma sp. SM16 derived from the marine sponge Dysidea sp., together with three known ones, aspergilloid G (3), rhinomilisin E (4), and rhinomilisin G (6). The complete structures of three new compounds were determined by HR-MS and NMR spectroscopic analyses coupled with ECD calculations. The absolute configurations of two known compounds (4 and 6) were determined for the first time. The six isolates were inactive as antibacterial agents. However, trichodermaloids A and B have shown cytotoxicity on human NCIH-460 lung, NCIC-H929 myeloma, and SW620 colorectal cancer cell lines with IC values at the range of 6.8-12.7 μm.
从海洋海绵 Dysidea sp. 共生真菌 Trichoderma sp. SM16 中分离到三个新的卡丹烷倍半萜，即 Trichodermaloids A（1）、B（2）和 C（5），以及三个已知化合物，aspergilloid G（3）、rhinomilisin E（4）和 rhinomilisin G（6）。通过高分辨质谱和 NMR 光谱分析与 ECD 计算相结合，确定了三个新化合物的完整结构。首次确定了两个已知化合物（4 和 6）的绝对构型。这六个分离物对作为抗菌剂没有活性。然而， Trichodermaloids A 和 B 对人非小细胞肺癌 NCIH-460、NCIC-H929 骨髓瘤和 SW620 结肠癌细胞系具有细胞毒性，IC 值范围为 6.8-12.7μm。
