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低血清Tat相互作用蛋白30水平是肝细胞癌的诊断和预后生物标志物。

A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma.

作者信息

Fan Sha-Sha, Liao Chu-Shu, Cao You-De, Xiao Pei-Ling, Deng Tan, Luo Rong-Cheng, Duan Hua-Xin

机构信息

Department of Oncology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, P.R. China.

Department of Oncology, Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Guangzhou, Guangdong 510315, P.R. China.

出版信息

Oncol Lett. 2017 Jun;13(6):4208-4214. doi: 10.3892/ol.2017.6024. Epub 2017 Apr 11.

DOI:10.3892/ol.2017.6024
PMID:28599422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5453031/
Abstract

The present study aimed to evaluate the diagnostic and prognostic value of Tat-interacting protein 30 (HTATIP2/TIP30) levels alone and in combination with α-fetoprotein (AFP) for the evaluation of hepatocellular carcinoma (HCC) patients. ELISA and immunohistochemical measurements on the serum and tissue of HTATIP2/TIP30 protein from HCC patients and normal controls were made. Receiver operating characteristic (ROC) curve analyses of AFP and HTATIP2/TIP30 were performed, as well as logistic regression analysis of APF combined with HTATIP2/TIP30. Log-rank analysis was used to correlate the prognosis with various levels of HTATIP2/TIP30. HTATIP2/TIP30 levels were significantly lower in the HCC group compared with the control group (4.50±2.63 vs. 9.50±2.04 ng/ml, P<0.001). ROC analysis revealed an optimal cut-off point at 7.27 ng/ml HTATIP2/TIP30 for separating the HCC from the control groups. The sensitivity and specificity were 84.6 and 93.7% (P<0.001), respectively. ROC areas of HTATIP2/TIP30 (0.928, P<0.001) were significantly higher than those for AFP (P<0.001). The area under the curve of the HTATIP2/TIP30 and AFP combination was 0.950 (P<0.001). Log-rank tests revealed that the recurrence-free survival time of the group with HTATIP2/TIP30>5.71 ng/ml was significantly higher than that of the control group (P<0.001). This is the first study to demonstrate that HTATIP2/TIP30 levels in serum may be an effective biomarker for the diagnosis and prognosis of HCC.

摘要

本研究旨在评估单独及联合甲胎蛋白（AFP）检测Tat相互作用蛋白30（HTATIP2/TIP30）水平对肝细胞癌（HCC）患者的诊断及预后价值。对HCC患者和正常对照者的血清及组织进行HTATIP2/TIP30蛋白的酶联免疫吸附测定（ELISA）和免疫组织化学检测。对AFP和HTATIP2/TIP30进行受试者操作特征（ROC）曲线分析，并对AFP与HTATIP2/TIP30进行逻辑回归分析。采用对数秩检验分析不同水平的HTATIP2/TIP30与预后的相关性。HCC组的HTATIP2/TIP30水平显著低于对照组（4.50±2.63对9.50±2.04 ng/ml，P<0.001）。ROC分析显示，HTATIP2/TIP30用于区分HCC组与对照组的最佳截断点为7.27 ng/ml。其敏感性和特异性分别为84.6%和93.7%（P<0.001）。HTATIP2/TIP30的ROC曲线下面积（0.928，P<0.001）显著高于AFP（P<0.001）。HTATIP2/TIP30与AFP联合检测的曲线下面积为0.950（P<0.001）。对数秩检验显示，HTATIP2/TIP30>5.71 ng/ml组的无复发生存时间显著长于对照组（P<0.001）。这是第一项证明血清中HTATIP2/TIP30水平可能是HCC诊断和预后有效生物标志物的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/cdcc4f23fd60/ol-13-06-4208-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/a80b55a2290a/ol-13-06-4208-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/b6b57fba9c29/ol-13-06-4208-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/2bcb04e77d70/ol-13-06-4208-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/361e2329efdc/ol-13-06-4208-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/2ec240edf7e2/ol-13-06-4208-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/cdcc4f23fd60/ol-13-06-4208-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/a80b55a2290a/ol-13-06-4208-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/b6b57fba9c29/ol-13-06-4208-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/2bcb04e77d70/ol-13-06-4208-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/361e2329efdc/ol-13-06-4208-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/2ec240edf7e2/ol-13-06-4208-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c330/5453031/cdcc4f23fd60/ol-13-06-4208-g05.jpg

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Int J Hepatol. 2013;2013:849290. doi: 10.1155/2013/849290. Epub 2013 Dec 19.
2
The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis.肝脏中的 EGFR 信号系统：从肝保护到肝癌发生。
J Gastroenterol. 2014 Jan;49(1):9-23. doi: 10.1007/s00535-013-0907-x. Epub 2013 Dec 10.
3
The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment.
低TIP30蛋白表达与非小细胞肺癌的高转移风险和不良预后相关。
J Clin Med. 2019 Jan 12;8(1):83. doi: 10.3390/jcm8010083.
4
Colorectal neoplasia differentially expressed: a long noncoding RNA with an imperative role in cancer.结直肠癌差异表达：一种在癌症中起关键作用的长链非编码RNA
Onco Targets Ther. 2018 Jun 29;11:3755-3763. doi: 10.2147/OTT.S162754. eCollection 2018.
5
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Chin Med J (Engl). 2018 Jan 20;131(2):188-193. doi: 10.4103/0366-6999.222325.
EGF-EGFR 信号通路在肝癌炎症微环境中的作用。
J Cell Mol Med. 2014 Feb;18(2):218-30. doi: 10.1111/jcmm.12153. Epub 2013 Nov 25.
4
Large-scale quantification of single amino-acid variations by a variation-associated database search strategy.通过变异关联数据库搜索策略对单氨基酸变异进行大规模定量分析。
J Proteome Res. 2014 Jan 3;13(1):241-8. doi: 10.1021/pr400544j. Epub 2013 Nov 25.
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