Dai Meiyu, Li Shan, Qin Xue
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China,
Onco Targets Ther. 2018 Jun 29;11:3755-3763. doi: 10.2147/OTT.S162754. eCollection 2018.
Colorectal neoplasia differentially expressed (CRNDE), as a long noncoding RNA (lncRNA), has attracted increasing attention in recent years and has been documented to be at abnormally high expression in various types of cancer, such as colorectal cancer, glioma, hepatocellular carcinoma, lung cancer, and breast cancer. It could not only be used as a clinical biomarker for the early diagnosis and prognosis evaluation in a variety of cancers but also promote the development and progress of various tumor cells. Moreover, it is involved in the targeting regulation of multiple microRNAs and the activation/inhibition of multiple signaling pathways. In this review, we presented a systematic summary of the potential carcinogenicity and clinical value of CRNDE in the current evidence, so as to provide reference for early diagnosis, prognosis evaluation, and targeted therapy of various clinical cancers.
结直肠癌差异表达基因（CRNDE）作为一种长链非编码RNA（lncRNA），近年来受到越来越多的关注，并且已被证明在多种类型的癌症中异常高表达，如结直肠癌、神经胶质瘤、肝细胞癌、肺癌和乳腺癌。它不仅可以作为多种癌症早期诊断和预后评估的临床生物标志物，还能促进各种肿瘤细胞的发展和进展。此外，它参与多种微小RNA的靶向调控以及多种信号通路的激活/抑制。在本综述中，我们对当前证据中CRNDE的潜在致癌性和临床价值进行了系统总结，以便为各种临床癌症的早期诊断、预后评估和靶向治疗提供参考。
