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Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis.癌症中的上皮-间质转化：白细胞介素-8/白细胞介素-8受体轴的作用
Oncol Lett. 2017 Jun;13(6):4577-4584. doi: 10.3892/ol.2017.6034. Epub 2017 Apr 13.
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c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC.c-Src激活通过PI3K/Akt信号通路诱导上皮-间质转化促进鼻咽癌转移：鼻咽癌的一个新的且有前景的靶点
Oncotarget. 2016 May 10;7(19):28340-55. doi: 10.18632/oncotarget.8634.
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Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells.肿瘤坏死因子-α通过丝裂原活化蛋白激酶激酶、p38和核因子κB调节人子宫内膜异位症上皮细胞中的炎症和间充质反应。
Mol Pharmacol. 2008 May;73(5):1394-404. doi: 10.1124/mol.107.042176. Epub 2008 Feb 5.
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Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network.Twist通过ITGB1-FAK/ILK信号轴及其相关的下游网络诱导乳腺癌中的上皮-间质转化和细胞迁移。
Int J Biochem Cell Biol. 2016 Feb;71:62-71. doi: 10.1016/j.biocel.2015.12.004. Epub 2015 Dec 13.
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PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/β-catenin signaling pathway.PMA 处理过的 THP-1 衍生的白细胞介素 6 通过 STAT3/ERK 依赖性激活 Wnt/β-连环蛋白信号通路促进 SW48 的 EMT。
Biomed Pharmacother. 2018 Dec;108:618-624. doi: 10.1016/j.biopha.2018.09.067. Epub 2018 Sep 20.
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The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.抑癌基因 SASH1 通过与信号接头蛋白 CRKL 相互作用抑制结直肠癌细胞上皮间质转化和转移
Cell Mol Gastroenterol Hepatol. 2018 Sep 11;7(1):33-53. doi: 10.1016/j.jcmgh.2018.08.007. eCollection 2019.
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Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition.细胞外信号调节激酶和 Akt 的激活在肝细胞生长因子诱导的上皮-间充质转化过程中起着关键作用。
Int J Oncol. 2013 Feb;42(2):556-64. doi: 10.3892/ijo.2012.1726. Epub 2012 Dec 3.
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PDGF-D/PDGFRβ promotes tongue squamous carcinoma cell (TSCC) progression via activating p38/AKT/ERK/EMT signal pathway.血小板衍生生长因子-D/血小板衍生生长因子受体β通过激活p38/AKT/ERK/上皮-间质转化信号通路促进舌鳞状细胞癌（TSCC）进展。
Biochem Biophys Res Commun. 2016 Sep 16;478(2):845-51. doi: 10.1016/j.bbrc.2016.08.035. Epub 2016 Aug 6.
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Simultaneous stimulation with tumor necrosis factor-α and transforming growth factor-β1 induces epithelial-mesenchymal transition in colon cancer cells via the NF-κB pathway.肿瘤坏死因子-α与转化生长因子-β1同时刺激通过核因子-κB途径诱导结肠癌细胞发生上皮-间质转化。
Oncol Lett. 2018 May;15(5):6873-6880. doi: 10.3892/ol.2018.8230. Epub 2018 Mar 12.
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Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells.旁分泌 IL-6 信号通过 Stat3/Nrf2 通路介导胰腺星状细胞对胰腺癌细胞上皮间质转化的影响。
Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):296-306. doi: 10.1016/j.bbagen.2016.10.006. Epub 2016 Oct 14.
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A novel chromen-based small molecule induces apoptosis and modulates cellular response to triple-negative breast cancer.一种新型的基于色烯的小分子可诱导细胞凋亡并调节对三阴性乳腺癌的细胞反应。
Sci Rep. 2025 Aug 29;15(1):31914. doi: 10.1038/s41598-025-16195-y.
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Senescence Promotes the Recovery of Stemness among Cancer Cells via Reprograming.衰老通过重编程促进癌细胞干性的恢复。
Biomolecules. 2024 Feb 28;14(3):288. doi: 10.3390/biom14030288.
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Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression.靶向上皮-间充质转化治疗气道重塑和肺纤维化进展的药物。
Can Respir J. 2023 Nov 29;2023:3291957. doi: 10.1155/2023/3291957. eCollection 2023.
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New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression.孕酮（P4）与PGRMC1/NENF复合物在结直肠癌进展中的相互作用新见解
Cancers (Basel). 2023 Oct 20;15(20):5074. doi: 10.3390/cancers15205074.
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Partial tumor irradiation plus pembrolizumab in treating large advanced solid tumor metastases.局部肿瘤放疗联合帕博利珠单抗治疗大型晚期实体瘤转移。
J Clin Invest. 2023 May 15;133(10):e162260. doi: 10.1172/JCI162260.
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Blocking the Hormone Receptors Modulates NLRP3 in LPS-Primed Breast Cancer Cells.阻断激素受体可调节 LPS 预刺激的乳腺癌细胞中的 NLRP3。
Int J Mol Sci. 2023 Mar 2;24(5):4846. doi: 10.3390/ijms24054846.
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Phytate Hydrolysate Differently Modulates the Immune Response of Human Healthy and Cancer Colonocytes to Intestinal Bacteria.植酸盐水解物对人健康结肠细胞和癌细胞的免疫反应有不同的调节作用。
Nutrients. 2022 Oct 11;14(20):4234. doi: 10.3390/nu14204234.
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The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma-Recent Findings and Review.炎症细胞因子在结直肠癌发病机制中的作用——最新发现与综述
Biomedicines. 2022 Jul 11;10(7):1670. doi: 10.3390/biomedicines10071670.
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Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy-An Integrated View into Other Neoplasms and Chemokine Networks.白细胞介素-8在黑色素瘤发病机制、预后及治疗中的作用——对其他肿瘤和趋化因子网络的综合观点
Cells. 2021 Dec 30;11(1):120. doi: 10.3390/cells11010120.
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本文引用的文献
1
Cisplatin promotes mesenchymal-like characteristics in osteosarcoma through Snail.顺铂通过Snail促进骨肉瘤中的间充质样特征。
Oncol Lett. 2016 Dec;12(6):5007-5014. doi: 10.3892/ol.2016.5342. Epub 2016 Nov 2.
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MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells.微小RNA-137和微小RNA-34a直接靶向蜗牛蛋白，并抑制卵巢癌细胞的上皮-间质转化、侵袭和球体形成能力。
J Exp Clin Cancer Res. 2016 Sep 5;35(1):132. doi: 10.1186/s13046-016-0415-y.
3
IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling.白细胞介素-8通过激活AKT信号传导诱导肾癌细胞的上皮-间质转化。
Oncol Lett. 2016 Sep;12(3):1915-1920. doi: 10.3892/ol.2016.4900. Epub 2016 Jul 21.
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Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.蜗牛 1 依赖性激活癌相关成纤维细胞控制上皮肿瘤细胞侵袭和转移。
Cancer Res. 2016 Nov 1;76(21):6205-6217. doi: 10.1158/0008-5472.CAN-16-0176. Epub 2016 Aug 8.
5
WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways.WSTF通过PI3K/Akt和IL-6/STAT3信号通路诱导上皮-间质转化（EMT），从而促进肺癌细胞的增殖和侵袭。
Cell Signal. 2016 Nov;28(11):1673-82. doi: 10.1016/j.cellsig.2016.07.008. Epub 2016 Jul 21.
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Necrotic cells influence migration and invasion of glioblastoma via NF-κB/AP-1-mediated IL-8 regulation.坏死细胞通过NF-κB/AP-1介导的IL-8调控影响胶质母细胞瘤的迁移和侵袭。
Sci Rep. 2016 Apr 14;6:24552. doi: 10.1038/srep24552.
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Curcumin inhibits tumor epithelial‑mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells.姜黄素通过下调Wnt信号通路和上调结肠癌细胞中NKD2的表达来抑制肿瘤上皮-间质转化。
Oncol Rep. 2016 May;35(5):2615-23. doi: 10.3892/or.2016.4669. Epub 2016 Mar 10.
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Icariside II inhibits the EMT of NSCLC cells in inflammatory microenvironment via down-regulation of Akt/NF-κB signaling pathway.淫羊藿次苷II通过下调Akt/NF-κB信号通路抑制炎症微环境中NSCLC细胞的上皮-间质转化
Mol Carcinog. 2017 Jan;56(1):36-48. doi: 10.1002/mc.22471. Epub 2016 Feb 9.
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Kindlin-2 promotes invasiveness of prostate cancer cells via NF-κB-dependent upregulation of matrix metalloproteinases.Kindlin-2通过NF-κB依赖性上调基质金属蛋白酶促进前列腺癌细胞的侵袭性。
Gene. 2016 Jan 15;576(1 Pt 3):571-6. doi: 10.1016/j.gene.2015.11.005. Epub 2015 Nov 10.
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VEGF silencing inhibits human osteosarcoma angiogenesis and promotes cell apoptosis via PI3K/AKT signaling pathway.血管内皮生长因子沉默通过PI3K/AKT信号通路抑制人骨肉瘤血管生成并促进细胞凋亡。
Int J Clin Exp Med. 2015 Aug 15;8(8):12411-7. eCollection 2015.
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