Rothwell N J, Stock M J
Comp Biochem Physiol A Comp Physiol. 1984;79(4):575-9. doi: 10.1016/0300-9629(84)90451-1.
Bilateral adrenalectomy markedly reduced body weight and energy gain and energetic efficiency of adult cafeteria-fed rats but enhanced the thermogenic response to food and stimulated brown fat activity. These changes were totally prevented by replacement of the animals with corticosterone (1 mg/rat/day). Unilateral denervation of the sympathetic nerves supplying the interscapular brown adipose tissue abolished the enhanced activity resulting from adrenalectomy and inhibited thermogenic activity in brown fat from cafeteria rats with intact adrenals, but had no effect in adrenalectomised animals treated with a high dose of corticosterone.
双侧肾上腺切除术显著降低了成年自由选择饮食喂养大鼠的体重、能量获取和能量效率，但增强了对食物的产热反应并刺激了棕色脂肪的活性。用皮质酮（1毫克/大鼠/天）替代动物可完全防止这些变化。对供应肩胛间棕色脂肪组织的交感神经进行单侧去神经支配，消除了肾上腺切除术导致的活性增强，并抑制了肾上腺完整的自由选择饮食大鼠棕色脂肪中的产热活性，但对用高剂量皮质酮治疗的肾上腺切除动物没有影响。
