Lin Ting-Yang, Lin Pei-Yin, Su Tung-Ping, Li Cheng-Ta, Lin Wei-Chen, Chang Wen-Hang, Chen Tzeng-Ji, Bai Ya-Mei, Chen Mu-Hong
Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan.
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Sleep Med. 2017 Aug;36:165-169. doi: 10.1016/j.sleep.2016.12.029. Epub 2017 Mar 10.
Previous cross-sectional studies have suggested a comorbid relationship between polycystic ovarian syndrome (PCOS) and obstructive sleep apnea (OSA). However, the temporal association between these two distinct diseases has not yet been investigated.
Using the Taiwan National Health Insurance Research Database, 4595 women with PCOS and 4595 (1:1) age-/sex-matched controls were enrolled into the present study between 1998 and 2009, and followed to the end of 2011. Those who developed OSA during the follow-up were identified.
Women with PCOS had a greater incidence of developing OSA (1.71 vs 0.63 1000 person-years, p < 0.001) than those without PCOS. The Cox regression analysis after adjusting for demographic data and medical comorbidities showed that women with PCOS had an elevated likelihood of subsequent OSA (hazard ratio: 2.63, 95% CI 1.57-4.04) during the follow-up compared to the controls.
Women with PCOS were associated with an increased risk of developing OSA in later life. Further studies would be required to investigate the underlying pathophysiology between PCOS and OSA, and to clarify whether prompt intervention for PCOS would reduce the risk of OSA.
既往横断面研究提示多囊卵巢综合征（PCOS）与阻塞性睡眠呼吸暂停（OSA）之间存在共病关系。然而，这两种不同疾病之间的时间关联尚未得到研究。
利用台湾国民健康保险研究数据库，1998年至2009年间纳入4595例PCOS女性及4595例（1:1）年龄和性别匹配的对照，并随访至2011年底。确定随访期间发生OSA的患者。
PCOS女性发生OSA的发生率（每1000人年1.71例vs 0.63例，p<0.001）高于无PCOS的女性。在调整人口统计学数据和合并症后进行的Cox回归分析显示，与对照组相比，PCOS女性在随访期间发生后续OSA的可能性升高（风险比：2.63，95%CI 1.57 - 4.04）。
PCOS女性在晚年发生OSA的风险增加。需要进一步研究来探究PCOS与OSA之间潜在的病理生理学机制，并明确对PCOS的及时干预是否会降低OSA的风险。
