Mukhi Priyabrata, Mohapatra Swapna Sarita, Bhattacharjee M, Ray K K, Muraleedharan T S, Arun A, Sathyavathi R, Juluri R R, Satyam P V, Panda Alok K, Biswas Ashis, Nayak S, Bojja Sreedhar, Pratihar S, Roy Sujit
School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751007, India.
Chemistry Department, Indian Institute of Technology, Kharagpur 721302, India.
J Ayurveda Integr Med. 2017 Apr-Jun;8(2):93-98. doi: 10.1016/j.jaim.2017.01.009. Epub 2017 Jun 7.
Mercury is one of the elements which had attracted the attention of the chemists and physicians of ancient India and China. Among the various metal based drugs which utilize mercury, we became interested in the red sulfide of mercury which is known in ancient Indian literature as rasasindur (alias rasasindura, rasasindoor, rasasinduram, sindur, or sindoor) and is used extensively in various ailments and diseases. Following various physico-chemical characterizations it is concluded that rasasindur is chemically pure α-HgS with Hg:S ratio as 1:1. Analysis of rasasindur vide Transmission Electron Microscopy (TEM) showed that the particles are in nanoscale. Bio-chemical studies of rasasindur were also demonstrated. It interacts with Bovine Serum Albumin (BSA) with an association constant of (9.76 ± 0.56) × 10 M and behaves as a protease inhibitor by inhibiting the proteolysis of BSA by trypsin. It also showed mild antioxidant properties.
汞是吸引古印度和中国化学家和医生关注的元素之一。在各种使用汞的金属基药物中，我们对红色硫化汞产生了兴趣，它在古印度文献中被称为rasasindur（别名rasasindura、rasasindoor、rasasinduram、sindur或sindoor），并广泛用于各种疾病。经过各种物理化学表征，得出rasasindur在化学上是纯净的α-HgS，汞与硫的比例为1:1。通过透射电子显微镜（TEM）对rasasindur的分析表明，颗粒处于纳米尺度。还对rasasindur进行了生化研究。它与牛血清白蛋白（BSA）相互作用，缔合常数为(9.76 ± 0.56) × 10 M，并通过抑制胰蛋白酶对BSA的蛋白水解作用而表现为蛋白酶抑制剂。它还表现出温和的抗氧化特性。
