Metastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Metastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Semin Cancer Biol. 2018 Apr;49:64-74. doi: 10.1016/j.semcancer.2017.05.010. Epub 2017 Jun 7.
Cancer is a disease characterised by uncontrolled growth and proliferation of cells. Tumours primarily show a higher rate of glucose uptake for lactate production even in the presence of functional mitochondria. An important metabolic consequence is intracellular formation of glucose-derived carbonyl reactive species such as methylglyoxal (MG). It has become clear that MG is the most potent glycation agent in our body, leading to alterations of proteins and DNA, and cellular dysfunction. In recent years, emerging evidence indicates that MG plays a role in the development of cancer. This review will examine studies regarding the effects of MG on cancer onset and progression and discuss their controversies. Finally, the utilisation of inhibitors and MG scavengers will be addressed in the context of MG-mediated stress blockade for cancer therapy.
癌症是一种以细胞失控生长和增殖为特征的疾病。肿瘤主要表现为即使在线粒体功能正常的情况下，也会以更高的速率摄取葡萄糖用于乳酸生成。一个重要的代谢后果是细胞内形成葡萄糖衍生的羰基反应性物质，如甲基乙二醛 (MG)。现在已经很清楚，MG 是我们体内最有效的糖化剂，导致蛋白质和 DNA 的改变以及细胞功能障碍。近年来，新出现的证据表明 MG 在癌症的发生和发展中起作用。这篇综述将检查关于 MG 对癌症发生和进展的影响的研究，并讨论它们的争议。最后，将在 MG 介导的应激阻断癌症治疗的背景下讨论抑制剂和 MG 清除剂的利用。
