Wen Jing, Zhang Qingya, Zhou Liyi
School of Food Science and Technology, Hunan Agricultural University Changsha Hunan 410125 China.
College of Food Science and Engineering, Central South University of Forestry and Technology Changsha Hunan 410004 China
RSC Adv. 2024 Dec 10;14(52):38757-38777. doi: 10.1039/d4ra07512a. eCollection 2024 Dec 3.
Methylglyoxal (MGO) plays an important role not only in physiological processes but also in pathological conditions, including diabetes, hypertension, and Alzheimer's disease. Therefore, developing accurate quantitative tools for MGO is of great significance for studying pathogenesis. Among the various methods available, the fluorescent probe method has garnered considerable attention due to its noninvasive detection capability, exceptional optical properties, good biocompatibility, and high sensitivity. In this review, we provide a brief overview of recent research on fluorescent probes used for MGO biosensing and bioimaging in living cells, tissues, and animals. Additionally, we summarize the advantages and existing challenges and also discuss future directions for development in this field.
甲基乙二醛（MGO）不仅在生理过程中发挥重要作用，而且在包括糖尿病、高血压和阿尔茨海默病在内的病理状况中也起着重要作用。因此，开发用于MGO的准确定量工具对于研究发病机制具有重要意义。在现有的各种方法中，荧光探针法因其无创检测能力、优异的光学性质、良好的生物相容性和高灵敏度而备受关注。在这篇综述中，我们简要概述了用于活细胞、组织和动物中MGO生物传感和生物成像的荧光探针的最新研究。此外，我们总结了其优点和现存挑战，并讨论了该领域未来的发展方向。
