美国国立癌症研究所基因组数据共享库作为精准医学的引擎。
The NCI Genomic Data Commons as an engine for precision medicine.
作者信息
Jensen Mark A, Ferretti Vincent, Grossman Robert L, Staudt Louis M
机构信息
Leidos Biomedical Research, Inc., Frederick, MD.
Ontario Institute for Cancer Research, Toronto, ON, Canada.
出版信息
Blood. 2017 Jul 27;130(4):453-459. doi: 10.1182/blood-2017-03-735654. Epub 2017 Jun 9.
Abstract
The National Cancer Institute Genomic Data Commons (GDC) is an information system for storing, analyzing, and sharing genomic and clinical data from patients with cancer. The recent high-throughput sequencing of cancer genomes and transcriptomes has produced a big data problem that precludes many cancer biologists and oncologists from gleaning knowledge from these data regarding the nature of malignant processes and the relationship between tumor genomic profiles and treatment response. The GDC aims to democratize access to cancer genomic data and to foster the sharing of these data to promote precision medicine approaches to the diagnosis and treatment of cancer.
摘要
美国国立癌症研究所基因组数据共享库（GDC）是一个用于存储、分析和共享癌症患者基因组及临床数据的信息系统。近期对癌症基因组和转录组进行的高通量测序产生了一个大数据问题，这使得许多癌症生物学家和肿瘤学家无法从这些数据中获取有关恶性肿瘤进程本质以及肿瘤基因组特征与治疗反应之间关系的知识。GDC旨在使获取癌症基因组数据的机会民主化，并促进这些数据的共享，以推动癌症诊断和治疗的精准医学方法。
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