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整合乳腺癌临床数据综述:统一平台视角

A Review on Integrating Breast Cancer Clinical Data: A Unified Platform Perspective.

作者信息

Kumar Ram Mohan Ram, Joghee Suresh

机构信息

Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

出版信息

Curr Treat Options Oncol. 2025 Jan;26(1):1-13. doi: 10.1007/s11864-024-01285-2. Epub 2025 Jan 3.

Abstract

Integrating clinical datasets in breast cancer research emerges as a necessary tool for advancing our knowledge of the disease and enhancing patient outcomes. Synthesizing diverse datasets offers advantages, from facilitating evidence-based insights to enabling predictive analytics and precision medicine strategies. Crucially, effective integration of clinical datasets necessitates collaborative efforts, policy interventions, and technological advancements to elevate global standards of breast cancer care. This narrative review underscores the imperative and substantial benefits of dataset integration in advancing breast cancer research and optimizing patient management. First, integrating diverse datasets-encompassing patient demographics, tumor characteristics, treatment modalities, and clinical outcomes-can significantly enhance our understanding of the disease's complexities and treatment responses across diverse patient populations. Second, we suggest that regulatory approval processes should allow new treatments to be conditionally approved for patients who were not part of the initial trials. This approval would depend on evaluating how well these treatments perform in real-world situations before full approval is granted. Third, we emphasize the importance of incorporating high-quality real-world evidence into treatment guidelines to better inform patient counselling and optimize personalized treatment strategies.

摘要

整合乳腺癌研究中的临床数据集已成为推进我们对该疾病的认识并改善患者治疗结果的必要工具。综合各种数据集具有诸多优势,从促进基于证据的见解到实现预测分析和精准医学策略。至关重要的是,临床数据集的有效整合需要协作努力、政策干预和技术进步,以提高全球乳腺癌护理标准。这篇叙述性综述强调了数据集整合在推进乳腺癌研究和优化患者管理方面的必要性和巨大益处。首先,整合包括患者人口统计学、肿瘤特征、治疗方式和临床结果在内的各种数据集,可以显著增强我们对不同患者群体中疾病复杂性和治疗反应的理解。其次,我们建议监管审批程序应允许新治疗方法有条件地批准用于未参与初始试验的患者。这种批准将取决于在全面批准之前评估这些治疗方法在现实世界中的表现。第三,我们强调将高质量的真实世界证据纳入治疗指南的重要性,以便更好地为患者咨询提供信息并优化个性化治疗策略。

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