富锶生物材料在骨再生中的临床应用：一项系统综述。
and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review.
作者信息
Neves N, Linhares D, Costa G, Ribeiro C C, Barbosa M A
机构信息
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto and Researcher, INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto and Lecturer Faculty of Medicine, University of Porto, Surgery Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto and Orthopaedic Surgeon Centro Hospitalar de São João, Orthopedic Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Orthopaedic Department, Centro Hospitalar de São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto and Researcher and Lecturer, MEDCIDS - Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto Portugal.
出版信息
Bone Joint Res. 2017 Jun;6(6):366-375. doi: 10.1302/2046-3758.66.BJR-2016-0311.R1.
OBJECTIVES
This systematic review aimed to assess the and clinical effect of strontium (Sr)-enriched biomaterials in bone formation and/or remodelling.
METHODS
A systematic search was performed in Pubmed, followed by a two-step selection process. We included original studies on Sr-containing biomaterials used for bone support or regeneration, comparing at least two groups that only differ in Sr addition in the experimental group.
RESULTS
A total of 572 references were retrieved and 27 were included. Animal models were used in 26 articles, and one article described a human study. Osteoporotic models were included in 11 papers. All articles showed similar or increased effect of Sr in bone formation and/or regeneration, in both healthy and osteoporotic models. No study found a decreased effect. Adverse effects were assessed in 17 articles, 13 on local and four on systemic adverse effects. From these, only one reported a systemic impact from Sr addition. Data on gene and/or protein expression were available from seven studies.
CONCLUSIONS
This review showed the safety and effectiveness of Sr-enriched biomaterials for stimulating bone formation and remodelling in animal models. The effect seems to increase over time and is impacted by the concentration used. However, included studies present a wide range of study methods. Future work should focus on consistent models and guidelines when developing a future clinical application of this element. N. Neves, D. Linhares, G. Costa, C. C. Ribeiro, M. A. Barbosa. and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review. 2017;6:366-375. DOI: 10.1302/2046-3758.66.BJR-2016-0311.R1.
目的
本系统评价旨在评估富锶（Sr）生物材料在骨形成和/或重塑中的安全性及临床效果。
方法
在PubMed进行系统检索，随后进行两步筛选过程。我们纳入了关于用于骨支撑或再生的含Sr生物材料的原始研究，比较了至少两组，实验组仅在Sr添加方面存在差异。
结果
共检索到572篇参考文献，纳入27篇。26篇文章使用了动物模型，1篇文章描述了人体研究。11篇论文纳入了骨质疏松模型。所有文章均表明，在健康和骨质疏松模型中，Sr在骨形成和/或再生方面具有相似或增强的效果。没有研究发现其效果降低。17篇文章评估了不良反应，13篇涉及局部不良反应，4篇涉及全身不良反应。其中，只有1篇报道了添加Sr对全身的影响。7项研究提供了基因和/或蛋白质表达数据。
结论
本综述表明，富锶生物材料在动物模型中刺激骨形成和重塑具有安全性和有效性。其效果似乎随时间增加，并受所用浓度影响。然而，纳入的研究呈现出广泛的研究方法。未来的工作在开发该元素的未来临床应用时应侧重于一致的模型和指南。N. 内维斯、D. 林哈雷斯、G. 科斯塔、C. C. 里贝罗、M. A. 巴尔博萨。富锶生物材料用于骨再生的安全性及临床应用：一项系统评价。2017；6：366 - 375。DOI：10.1302/2046 - 3758.66.BJR - 2016 - 0311.R1。
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