Keilani M, Hasenoehrl T, Baumann L, Ristl R, Schwarz M, Marhold M, Sedghi Komandj T, Crevenna R
Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Comprehensive Cancer Center, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Section of Medical Statistics, CeMSIIS, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Support Care Cancer. 2017 Sep;25(9):2953-2968. doi: 10.1007/s00520-017-3771-z. Epub 2017 Jun 10.
The aim of the present meta-analysis was to quantify effects of resistance exercise (RE) on physical performance and function, body composition, health-related quality of life (HRQoL), and fatigue in patients with prostate cancer.
Trial data were obtained from the databases PubMed, MEDLINE, EMBASE, SCOPUS, and the Cochrane Library as of inception to 31st of December 2016. Thirty-two trials with 1199 patients were included. Results that were measured by using the same assessment method in five or more of the original studies were pooled in a meta-analysis.
Pooled studies showed significant improvements of muscular strength in the upper and lower body (95% CI [2.52, 7.97] kg; p < 0.001 and 95% CI [10.51, 45.88] kg; p = 0.008, respectively) after RE. Furthermore, significant improvements were seen for body composition (body fat percentage 95% CI [-0.79, -0.53] %; p < 0.001; lean body mass 95% CI [0.15, 1.84] %; p = 0.028; trunk fat mass 95% CI [-0.73, -0.08] kg; p = 0.024). Additionally, the improvement of the 400-m walk time was significant (95% CI [-21.55, -14.65] s; p < 0.001). Concerning fatigue and HRQoL, there were not sufficient data for analysis.
RE seems to be a promising approach in order to counteract loss of muscle mass, muscle strength, and physical performance in patients suffering from prostate cancer and its treatment-related side effects. RE should play part in interdisciplinary cancer rehabilitation and care of this patient group. Nevertheless, further research should investigate RE further to determine which protocols are the most pragmatic, yet yielding best patient outcomes.
本荟萃分析的目的是量化抗阻运动（RE）对前列腺癌患者身体机能和功能、身体成分、健康相关生活质量（HRQoL）以及疲劳的影响。
截至2016年12月31日，从PubMed、MEDLINE、EMBASE、SCOPUS和Cochrane图书馆数据库中获取试验数据。纳入了32项试验，共1199例患者。在五项或更多原始研究中使用相同评估方法测量的结果进行荟萃分析汇总。
汇总研究显示，抗阻运动后上半身和下半身肌肉力量有显著改善（分别为95%可信区间[2.52, 7.97]kg；p < 0.001和95%可信区间[10.51, 45.88]kg；p = 0.008）。此外，身体成分也有显著改善（体脂百分比95%可信区间[-0.79, -0.53]%；p < 0.001；去脂体重95%可信区间[0.15, 1.84]%；p = 0.028；躯干脂肪量95%可信区间[-0.73, -0.08]kg；p = 0.024）。此外，400米步行时间也有显著改善（95%可信区间[-21.55, -14.65]秒；p < 0.001）。关于疲劳和健康相关生活质量，没有足够的数据进行分析。
抗阻运动似乎是一种有前景的方法，可抵消前列腺癌患者及其治疗相关副作用导致的肌肉量、肌肉力量和身体机能的丧失。抗阻运动应在该患者群体的多学科癌症康复和护理中发挥作用。然而，进一步的研究应进一步调查抗阻运动，以确定哪些方案最实用且能产生最佳的患者预后。
