Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Peripher Nerv Syst. 2017 Sep;22(3):156-161. doi: 10.1111/jns.12226. Epub 2017 Jul 2.
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a potentially dose-limiting side effect of the treatment of several cancers. CIPN is predominantly or exclusively sensory, and it is frequently associated with unpleasant symptoms, overall referred to as "pain." However, given the markedly different clinical presentation and course of CIPN depending on the antineoplastic drug used, the broad term "pain" in the specific context of CIPN needs to be reconsidered and refined. In fact, a precise identification of the features of CIPN has relevant implication in the design of rational-based clinical trials and in the selection of possible active drugs.
化疗引起的周围神经毒性（CIPN）是几种癌症治疗中潜在的剂量限制副作用。CIPN 主要或完全是感觉性的，常伴有不愉快的症状，通常被称为“疼痛”。然而，鉴于 CIPN 的临床表现和病程因使用的抗肿瘤药物而异，在 CIPN 的具体情况下，“疼痛”这一广义术语需要重新考虑和细化。事实上，对 CIPN 特征的准确识别在基于合理设计的临床试验设计和可能的有效药物选择中具有重要意义。
