Pieri M, Storto M, Pignalosa S, Zenobi R, Buttari F, Bernardini S, Centonze D, Dessi M
Department of Experimental Medicine and Surgery, "Tor Vergata" University Hospital, Rome, Italy.
Clinical Pathology Unit, IRCCS Neuromed, Pozzilli, IS, Italy.
J Neuroimmunol. 2017 Aug 15;309:31-33. doi: 10.1016/j.jneuroim.2017.05.007. Epub 2017 May 12.
The Multiple Sclerosis (MS) diagnosis is based on dissemination of focal lesions in time and space. The free light chains (FLCs) determination might be a sensitive alternative to oligoclonal bands assay. The study aim was to redefine sensitivity, specificity of the kFLC Index cut-off. We analyzed serum and cerebrospinal fluid of 176 patients, with different neurological disorders. We obtained a cut off of 12,3 for kFLC Index with a sensitivity and specificity of 93% and 100% respectively. Our data confirm that the kFLC Index is a valid tool in the diagnosis of MS.
多发性硬化症（MS）的诊断基于局灶性病变在时间和空间上的播散。游离轻链（FLC）测定可能是寡克隆带检测的一种敏感替代方法。本研究的目的是重新定义kFLC指数临界值的敏感性和特异性。我们分析了176例患有不同神经系统疾病患者的血清和脑脊液。我们得出kFLC指数的临界值为12.3，敏感性和特异性分别为93%和100%。我们的数据证实kFLC指数是MS诊断中的一种有效工具。
