Jensen Camilla B, Lundqvist Marika, Sørensen Thorkild I A, Heitmann Berit L
Department of Clinical Epidemiology (formerly Institute of Preventive Medicine), Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Denmark.
Obes Facts. 2017;10(3):273-283. doi: 10.1159/000471881. Epub 2017 Jun 10.
Vitamin D level in pregnancy may be associated with risk of overweight in the offspring later in life.
In a case-cohort study based on Danish biobanks and registers we examined the association between 25-hydroxy-vitamin D (25(OH)D) level at birth and overweight at 7 years. Cases of overweight (n = 871) were randomly selected among 7-year-old children from the Copenhagen School Health Records Register (CSHRR) with a BMI above the 90th percentile. The cohort (n = 1,311) was a random sample selected among all Danish children born during the same period. Neonatal 25(OH)D was measured in dried blood spots.
25(OH)D3 exhibited the expected seasonal variation. Median level of 25(OH)D3 was 20.6 (11.9-33.3) nmol/l in the overweight group and 23.4 (13.5-34.3) nmol/l in the cohort. We found no association between neonatal 25(OH)D3 level and risk of overweight at age 7 years, neither in the crude model (OR (CI) 1.00 (0.99; 1.00)) nor in a model adjusted for maternal ethnicity, educational level, civil status, parity, season and year of birth, and offspring ponderal index (OR (CI) 1.00 (0.99; 1.01)).
Risk of overweight at 7 years of age was not associated with vitamin D level at birth.
孕期维生素D水平可能与后代日后超重风险相关。
在一项基于丹麦生物样本库和登记册的病例对照研究中，我们研究了出生时25-羟基维生素D（25(OH)D）水平与7岁时超重之间的关联。超重病例（n = 871）从哥本哈根学校健康记录登记册（CSHRR）中BMI高于第90百分位数的7岁儿童中随机选取。队列（n = 1311）是从同期出生的所有丹麦儿童中随机抽取的样本。新生儿25(OH)D在干血斑中进行测量。
25(OH)D3呈现出预期的季节性变化。超重组中25(OH)D3的中位数水平为20.6（11.9 - 33.3）nmol/l，队列中为23.4（13.5 - 34.3）nmol/l。我们发现新生儿25(OH)D3水平与7岁时超重风险之间无关联，在粗模型中（OR（CI）1.00（0.99；1.00））以及在调整了母亲种族、教育水平、婚姻状况、产次、出生季节和年份以及后代 ponderal 指数的模型中（OR（CI）1.00（0.99；1.01））均无关联。
7岁时的超重风险与出生时的维生素D水平无关。
