Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Diabetologia. 2021 Jul;64(7):1572-1582. doi: 10.1007/s00125-021-05450-2. Epub 2021 May 24.
AIMS/HYPOTHESIS: The aim of this study was to examine the influence of neonatal vitamin D concentration on the development of early-onset type 2 diabetes in a large population sample.
We conducted a case-cohort study utilising data from the Danish biobank and registers. Neonatal vitamin D was assessed measuring 25-hydroxyvitamin D [25(OH)D] concentrations on the dried blood spot samples from the Biological Specimen Bank for Neonatal Screening. Cases of type 2 diabetes (n = 731) were retrieved from the Danish National Patient Register for all individuals born in Denmark between 1 May 1981 and 31 December 1992. The sub-cohort (n = 1765) was randomly selected from all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first type 2 diabetes diagnoses by quintiles of 25(OH)D and restricted cubic spline.
The median 25(OH)D concentration (IQR) among cases was 21.3 nmol/l (13.3-34.1) and 23.9 nmol/l (13.7-35.7) in the sub-cohort. There was no indication of a potential lower risk of early-onset type 2 diabetes among individuals in the higher quintile of vitamin D concentration compared with the lowest (HR 0.97 [95% CI 0.71, 1.33] p = 0.85; HR 1.29 [95% CI 0.92, 1.83] p = 0.14).
CONCLUSIONS/INTERPRETATION: The results of this study do not support the hypothesis that higher neonatal vitamin D concentrations are associated with a lower risk of early-onset type 2 diabetes in adulthood.
目的/假设：本研究旨在检查新生儿维生素 D 浓度对大型人群样本中早发性 2 型糖尿病发展的影响。
我们利用丹麦生物库和登记处的数据进行了病例-队列研究。通过对新生儿筛查生物标本银行的干血斑样本测量 25-羟维生素 D [25(OH)D] 浓度，评估新生儿维生素 D。从丹麦国家患者登记处检索所有 1981 年 5 月 1 日至 1992 年 12 月 31 日期间在丹麦出生的个体的 2 型糖尿病病例（n=731）。从同一时期出生的所有儿童中随机选择亚队列（n=1765）。我们使用加权 Cox 比例风险模型评估按 25(OH)D 五分位数和限制立方样条的五分位数评估首次 2 型糖尿病诊断的风险。
病例组的中位数 25(OH)D 浓度（IQR）为 21.3 nmol/L（13.3-34.1），亚队列为 23.9 nmol/L（13.7-35.7）。与最低五分位数相比，维生素 D 浓度较高五分位数的个体发生早发性 2 型糖尿病的风险没有降低的迹象（HR 0.97 [95% CI 0.71, 1.33] p=0.85；HR 1.29 [95% CI 0.92, 1.83] p=0.14）。
结论/解释：本研究结果不支持较高的新生儿维生素 D 浓度与成年后早发性 2 型糖尿病风险降低相关的假设。
