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经组织学证实的阿尔茨海默病痴呆患者腰椎脑脊液中的推定氨基酸递质。

Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.

作者信息

Smith C C, Bowen D M, Francis P T, Snowden J S, Neary D

出版信息

J Neurol Neurosurg Psychiatry. 1985 May;48(5):469-71. doi: 10.1136/jnnp.48.5.469.

DOI:10.1136/jnnp.48.5.469
PMID:2860210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1028335/
Abstract

Concentrations of individual free amino acids were determined in lumbar cerebrospinal fluid (CSF) from patients with various complaints including histologically verified Alzheimer's dementia. Glycine and glutamine in the CSF of Alzheimer's dementia samples were lower than that of control samples. Only the concentration of glutamic acid in Alzheimer's dementia patients correlated with psychological measures. The reduction in glycine concentration was not specific for Alzheimer's dementia.

摘要

对包括经组织学证实的阿尔茨海默病痴呆症患者在内的各种有不同症状的患者的腰椎脑脊液（CSF）中的游离氨基酸个体浓度进行了测定。阿尔茨海默病痴呆症样本脑脊液中的甘氨酸和谷氨酰胺低于对照样本。在阿尔茨海默病痴呆症患者中，只有谷氨酸浓度与心理测量指标相关。甘氨酸浓度的降低并非阿尔茨海默病痴呆症所特有。

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