Pomara N, Singh R, Deptula D, Chou J C, Schwartz M B, LeWitt P A
Lafayette Clinic, Detroit, Mich.
Am J Psychiatry. 1992 Feb;149(2):251-4. doi: 10.1176/ajp.149.2.251.
The authors compared CSF amino acid levels of 10 patients with mild to moderate dementia and probable Alzheimer's disease who had never received antidepressant or neuroleptic medication with those of 10 normal subjects of similar age. The Alzheimer's patients had significantly higher levels of CSF glutamate. This finding was not related to age, sex, or severity of dementia. Elevated CSF glutamate may reflect greater glutamatergic activity early in the course of Alzheimer's disease. The authors speculate that the excitotoxic effects of glutamate may contribute to progressive neuronal loss in Alzheimer's disease.
作者将10例从未接受过抗抑郁药或抗精神病药物治疗的轻度至中度痴呆且可能患有阿尔茨海默病的患者的脑脊液氨基酸水平与10名年龄相仿的正常受试者进行了比较。阿尔茨海默病患者的脑脊液谷氨酸水平显著更高。这一发现与年龄、性别或痴呆严重程度无关。脑脊液谷氨酸水平升高可能反映了阿尔茨海默病病程早期谷氨酸能活性增强。作者推测，谷氨酸的兴奋性毒性作用可能导致阿尔茨海默病中神经元的进行性丧失。
