Pharmacology Laboratory, Medecine Faculty, Constantine 3 University, Algeria.
Toxicology Laboratory, Medecine Faculty, Constantine 3 University, Algeria.
Toxicol In Vitro. 2017 Dec;45(Pt 3):393-396. doi: 10.1016/j.tiv.2017.05.024. Epub 2017 Jun 8.
The use of in vitro methods for the control of cosmetic products in developing countries must overcome cost, feasibility and an unfavourable regulatory environment. Among these products, shampoos occupy an important part of the market but present a number of risks related to their use like eye irritation. The aim of this work is to propose the HET-CAM test as a method of screening the risk of eye irritation of shampoos, adapting it to the technical and regulatory conditions of a developing country such as Algeria.
6 locally produced shampoos (4 adults and 2 for babies) were tested at 100%, 50%, 25%, 10%, 5%, 2.5% and 1.5%.
The use of a 10% dilution classifies the baby and adult shampoos in two different categories of irritation. A benchmark approach can be applied using this concentration to evaluate the ocular irritative risk of adult and baby shampoos in developing countries.
在发展中国家，为控制化妆品而使用体外方法必须克服成本、可行性和不利的监管环境等问题。在这些产品中，洗发水占据了很大一部分市场，但在使用过程中存在一些风险，例如眼睛刺激。本工作旨在提出 HET-CAM 试验作为一种筛选洗发水眼睛刺激风险的方法，使其适应发展中国家（如阿尔及利亚）的技术和监管条件。
对 6 种本地生产的洗发水（4 种成人用和 2 种婴儿用）进行了 100%、50%、25%、10%、5%、2.5%和 1.5%的测试。
使用 10%的稀释液将婴儿和成人洗发水分为两种不同的刺激类别。可以使用此浓度的基准方法来评估发展中国家成人和婴儿洗发水的眼部刺激性风险。
