He Liangmei, Xiao Xiaomei, Yang Xi, Zhang Zixiang, Wu Longhuo, Liu Zhiping
The First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi, 341000, China.
School of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, 341000, China.
Cancer Lett. 2017 Aug 28;402:203-212. doi: 10.1016/j.canlet.2017.05.026. Epub 2017 Jun 7.
Stimulator of interferon genes (STING) is a DNA sensor and an important cytoplasmic adaptor for other DNA sensors, such as Z-DNA binding protein 1 (DAI), DEAD-box helicase 41 (DDX41), and interferon-γ-inducible protein 16 (IFI16). The activation of STING signaling leads to the production of type I interferons and some other pro-inflammatory cytokines, which are critical for host defense against viral infection. Recent accumulating evidences suggest that STING is also involved in tumor development. However, the role of STING signaling in tumorigenesis is complicated, and a comprehensive review is still lacking. In this paper, we provided an overview of the dual role of STING signaling in tumor development from clinical significance to fundamental mechanisms, as well as its pre-clinical application in cancer therapy.
干扰素基因刺激因子（STING）是一种DNA传感器，也是其他DNA传感器（如Z-DNA结合蛋白1（DAI）、解旋酶DEAD盒41（DDX41）和干扰素γ诱导蛋白16（IFI16））的重要细胞质衔接蛋白。STING信号通路的激活会导致I型干扰素和其他一些促炎细胞因子的产生，这些对于宿主抵御病毒感染至关重要。最近越来越多的证据表明，STING也参与肿瘤发展。然而，STING信号通路在肿瘤发生中的作用很复杂，目前仍缺乏全面的综述。在本文中，我们从临床意义到基本机制概述了STING信号通路在肿瘤发展中的双重作用，以及其在癌症治疗中的临床前应用。
