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Synergy of Transforming Growth Factor Beta 1 and All Trans Retinoic Acid in the Treatment of Inflammatory Bowel Disease: Role of Regulatory T cells.

作者信息

Auci Dominick L, Egilmez Nejat K

机构信息

Research and Development Therapy Xinc, Buffalo, NY.

University of Louisville, Department of Microbiology and Immunology, Louisville, KY.

出版信息

J Gastroenterol Pancreatol Liver Disord. 2016;3(4). doi: 10.15226/2374-815X/3/4/00166. Epub 2016 Aug 11.

DOI:10.15226/2374-815X/3/4/00166
PMID:28603774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5462338/
Abstract
摘要

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本文引用的文献

1
Oral Delivery of Particulate Transforming Growth Factor Beta 1 and All-Trans Retinoic Acid Reduces Gut Inflammation in Murine Models of Inflammatory Bowel Disease.微粒状转化生长因子β1和全反式维甲酸的口服给药可减轻炎症性肠病小鼠模型的肠道炎症。
J Crohns Colitis. 2015 Aug;9(8):647-58. doi: 10.1093/ecco-jcc/jjv089. Epub 2015 May 18.
2
Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues.去甲异波尔定通过调节肠道相关淋巴组织中Th17细胞与调节性T细胞之间的平衡来改善胶原诱导的关节炎。
Toxicol Appl Pharmacol. 2015 Jan 1;282(1):90-9. doi: 10.1016/j.taap.2014.11.008. Epub 2014 Dec 3.
3
Negative interplay of retinoic acid and TGF-β signaling mediated by TG-interacting factor to modulate mouse embryonic palate mesenchymal-cell proliferation.由TG相互作用因子介导的视黄酸与转化生长因子-β信号的负相互作用，以调节小鼠胚胎腭间充质细胞增殖。
Birth Defects Res B Dev Reprod Toxicol. 2014 Dec;101(6):403-9. doi: 10.1002/bdrb.21130. Epub 2014 Dec 4.
4
Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells.口服白细胞介素-10 通过中和致病性 T 调节细胞来缓解息肉病。
Cancer Res. 2014 Oct 1;74(19):5377-85. doi: 10.1158/0008-5472.CAN-14-0918. Epub 2014 Sep 16.
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Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells.维甲酸使人类树突状细胞致敏，以诱导归巢至肠道、产生白细胞介素-10的调节性T细胞。
Mucosal Immunol. 2015 Mar;8(2):265-78. doi: 10.1038/mi.2014.64. Epub 2014 Jul 16.
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All-trans retinoic acid attenuates experimental colitis through inhibition of NF-κB signaling.全反式维甲酸通过抑制核因子κB信号通路减轻实验性结肠炎。
Immunol Lett. 2014 Nov;162(1 Pt A):34-40. doi: 10.1016/j.imlet.2014.06.011. Epub 2014 Jul 6.
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Retinoic acid induced repair in the lung of adult hyperoxic mice, reducing transforming growth factor-β1 (TGF-β1) mediated abnormal alterations.维甲酸诱导成年高氧小鼠肺修复，减少转化生长因子-β1（TGF-β1）介导的异常改变。
Acta Histochem. 2014 Jun;116(5):810-9. doi: 10.1016/j.acthis.2014.01.009. Epub 2014 Feb 24.