Leal Mariana C, van der Linden Vanessa, Bezerra Thiago P, de Valois Luciana, Borges Adriana C G, Antunes Margarida M C, Brandt Kátia G, Moura Catharina X, Rodrigues Laura C, Ximenes Coeli R
Emerg Infect Dis. 2017 Aug;23(8):1253-1259. doi: 10.3201/eid2308.170354. Epub 2017 Aug 15.
We summarize the characteristics of dysphagia in 9 infants in Brazil with microcephaly caused by congenital Zika virus infection. The Schedule for Oral Motor Assessment, fiberoptic endoscopic evaluation of swallowing, and the videofluoroscopic swallowing study were used as noninstrumental and instrumental assessments. All infants had a degree of neurologic damage and showed abnormalities in the oral phase. Of the 9 infants, 8 lacked oral and upper respiratory tract sensitivity, leading to delays in initiation of the pharyngeal phase of swallowing. Those delays, combined with marked oral dysfunction, increased the risk for aspiration of food, particularly liquid foods. Dysphagia resulting from congenital Zika virus syndrome microcephaly can develop in infants >3 months of age and is severe.
我们总结了巴西9例因先天性寨卡病毒感染导致小头畸形的婴儿吞咽困难的特征。采用口腔运动评估量表、纤维内镜吞咽功能检查和电视荧光吞咽造影检查作为非仪器和仪器评估方法。所有婴儿均有一定程度的神经损伤，且在口腔期表现异常。9例婴儿中，8例缺乏口腔和上呼吸道敏感性，导致吞咽咽期启动延迟。这些延迟与明显的口腔功能障碍相结合，增加了食物误吸的风险，尤其是液体食物。先天性寨卡病毒综合征小头畸形导致的吞咽困难可在3个月以上的婴儿中出现，且较为严重。
